Enhanced cytotoxicity of a Pseudomonas Exotoxin A based immunotoxin against prostate cancer by addition of the endosomal escape enhancer SO1861

Immunotoxins consist of an antibody or antibody fragment that binds to a specific cell surface structure and a cytotoxic domain that kills the cell after cytosolic uptake. Pseudomonas Exotoxin A (PE) based immunotoxins directed against a variety of tumor entities have successfully entered the clinic...

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Detalles Bibliográficos
Autores principales: Masilamani, Anie P., Huber, Nathalie, Nagl, Constanze, Dettmer-Monaco, Viviane, Monaco, Gianni, Wolf, Isis, Schultze-Seemann, Susanne, Taromi, Sanaz, Gratzke, Christian, Fuchs, Hendrik, Wolf, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358361/
https://www.ncbi.nlm.nih.gov/pubmed/37484018
http://dx.doi.org/10.3389/fphar.2023.1211824

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