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Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history

As the efficacy of chemotherapy and adjuvant endocrine therapy for breast cancer increase, the quality-of-life to cancer survivors could be more important issue in strategies of breast cancer treatment. Bone health has become more compelling in care of breast cancer survivor than ever before. This r...

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Autores principales: Lee, Ji Han, Kim, Yong Jin, Kim, Sung Woo, Kim, Hoon, Han, Wonshik, Ku, Seung-Yup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358553/
https://www.ncbi.nlm.nih.gov/pubmed/33733929
http://dx.doi.org/10.1177/00368504211000515
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author Lee, Ji Han
Kim, Yong Jin
Kim, Sung Woo
Kim, Hoon
Han, Wonshik
Ku, Seung-Yup
author_facet Lee, Ji Han
Kim, Yong Jin
Kim, Sung Woo
Kim, Hoon
Han, Wonshik
Ku, Seung-Yup
author_sort Lee, Ji Han
collection PubMed
description As the efficacy of chemotherapy and adjuvant endocrine therapy for breast cancer increase, the quality-of-life to cancer survivors could be more important issue in strategies of breast cancer treatment. Bone health has become more compelling in care of breast cancer survivor than ever before. This retrospective study was aimed to evaluate factors relating to the change in BMD and to ascertain the correlation between changes in BMD and EMT of women with breast cancer in follow-up. Records of 164 women who underwent surgery for breast cancer were reviewed in this study. The basal characteristics included parity, menopausal state, medication with vitamin D, bisphosphonate, selective estrogen modulator (SERM), aromatase inhibitor (AI), gonadotrophin releasing hormone agonist (GnRHa), chemotherapy, radiotherapy, cancer type including positivity of estrogen receptor, progesterone receptor and HER2, combined the other gynecologic disease or the other origin cancer. At initial and follow-up visit, all subjective were checked with BMD, endometrial thickness (EMT). The mean age was 52.1 ± 8.5 years old and overall interval between initial and follow-up visits were 17.6 ± 7.5 month in this study. The BMDs of L1–4 (1.040 ± 0.166 g/cm(2) vs 1.070 ± 0.181 g/cm(2), p < 0.001), femur neck (0.850 ± 0.121 g/cm(2) vs 0.870 ± 0.136 g/cm(2), p < 0.001), and femur total (0.902 ± 0.132 g/cm(2) vs 0.915 ± 0.138 g/cm(2), p < 0.001) at follow-up visit were significantly lower than those at initial visit. The change in BMDs of L1–4 (ΔBMD(L1–4), r = 0.353, p < 0.001, and r = 0.228, p = 0.003), femur neck (ΔBMD(Neck), r = 0.198, p = 0.011, and r = 0.282, p < 0.001), femur total (ΔBMD(Total), r = 0.294, p < 0.001, and r = 0.327, p < 0.001) had positive correlation with age and the change in EMT (ΔEMT). After age correction, ΔEMT had positive correlation with ΔBMD(Neck) (r = 0.245, p = 0.002) and ΔBMD(Total) (r = 0.273, p < 0.001). ΔBMD(L1–4) and ΔBMD(Neck) differed according to menopausal state (p < 0.001 and p = 0.035), bisphosphonate (p < 0.001 and p < 0.001), and GnRHa (p < 0.001 and p < 0.001). In follow-up of women with history of breast cancer, ΔEMT could be an alternative screening marker for BMD decrease.
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spelling pubmed-103585532023-08-09 Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history Lee, Ji Han Kim, Yong Jin Kim, Sung Woo Kim, Hoon Han, Wonshik Ku, Seung-Yup Sci Prog Article As the efficacy of chemotherapy and adjuvant endocrine therapy for breast cancer increase, the quality-of-life to cancer survivors could be more important issue in strategies of breast cancer treatment. Bone health has become more compelling in care of breast cancer survivor than ever before. This retrospective study was aimed to evaluate factors relating to the change in BMD and to ascertain the correlation between changes in BMD and EMT of women with breast cancer in follow-up. Records of 164 women who underwent surgery for breast cancer were reviewed in this study. The basal characteristics included parity, menopausal state, medication with vitamin D, bisphosphonate, selective estrogen modulator (SERM), aromatase inhibitor (AI), gonadotrophin releasing hormone agonist (GnRHa), chemotherapy, radiotherapy, cancer type including positivity of estrogen receptor, progesterone receptor and HER2, combined the other gynecologic disease or the other origin cancer. At initial and follow-up visit, all subjective were checked with BMD, endometrial thickness (EMT). The mean age was 52.1 ± 8.5 years old and overall interval between initial and follow-up visits were 17.6 ± 7.5 month in this study. The BMDs of L1–4 (1.040 ± 0.166 g/cm(2) vs 1.070 ± 0.181 g/cm(2), p < 0.001), femur neck (0.850 ± 0.121 g/cm(2) vs 0.870 ± 0.136 g/cm(2), p < 0.001), and femur total (0.902 ± 0.132 g/cm(2) vs 0.915 ± 0.138 g/cm(2), p < 0.001) at follow-up visit were significantly lower than those at initial visit. The change in BMDs of L1–4 (ΔBMD(L1–4), r = 0.353, p < 0.001, and r = 0.228, p = 0.003), femur neck (ΔBMD(Neck), r = 0.198, p = 0.011, and r = 0.282, p < 0.001), femur total (ΔBMD(Total), r = 0.294, p < 0.001, and r = 0.327, p < 0.001) had positive correlation with age and the change in EMT (ΔEMT). After age correction, ΔEMT had positive correlation with ΔBMD(Neck) (r = 0.245, p = 0.002) and ΔBMD(Total) (r = 0.273, p < 0.001). ΔBMD(L1–4) and ΔBMD(Neck) differed according to menopausal state (p < 0.001 and p = 0.035), bisphosphonate (p < 0.001 and p < 0.001), and GnRHa (p < 0.001 and p < 0.001). In follow-up of women with history of breast cancer, ΔEMT could be an alternative screening marker for BMD decrease. SAGE Publications 2021-03-18 /pmc/articles/PMC10358553/ /pubmed/33733929 http://dx.doi.org/10.1177/00368504211000515 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Article
Lee, Ji Han
Kim, Yong Jin
Kim, Sung Woo
Kim, Hoon
Han, Wonshik
Ku, Seung-Yup
Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history
title Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history
title_full Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history
title_fullStr Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history
title_full_unstemmed Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history
title_short Correlation between bone mineral density and endometrial thickness over time in women with breast cancer history
title_sort correlation between bone mineral density and endometrial thickness over time in women with breast cancer history
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358553/
https://www.ncbi.nlm.nih.gov/pubmed/33733929
http://dx.doi.org/10.1177/00368504211000515
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