Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa

Resistant Gram-negative bacteria are a growing concern in the United States, leading to significant morbidity and mortality. We identified a 72-year-old female patient who presented with unilateral vision loss. She was found to have a large corneal ulcer with hypopyon. Culture of corneal scrapings g...

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Detalles Bibliográficos
Autores principales: Morelli, Morgan K., Kloosterboer, Amy, Fulton, Scott A., Furin, Jennifer, Newman, Nicholas, Omar, Ahmed F., Rojas, Laura J., Marshall, Steven H., Yasmin, Mohamad, Bonomo, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Challenging Clinical Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358754/
https://www.ncbi.nlm.nih.gov/pubmed/37166191
http://dx.doi.org/10.1128/aac.00277-23
Descripción
Sumario:Resistant Gram-negative bacteria are a growing concern in the United States, leading to significant morbidity and mortality. We identified a 72-year-old female patient who presented with unilateral vision loss. She was found to have a large corneal ulcer with hypopyon. Culture of corneal scrapings grew extensively drug-resistant Pseudomonas aeruginosa. Treatment involved a combination of systemic and topical antibiotics. Whole genome sequencing revealed the presence of bla(VIM-80), bla(GES-9), and other resistance determinants. This distinctive organism was linked to an over-the-counter artificial tears product.

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