Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa

Resistant Gram-negative bacteria are a growing concern in the United States, leading to significant morbidity and mortality. We identified a 72-year-old female patient who presented with unilateral vision loss. She was found to have a large corneal ulcer with hypopyon. Culture of corneal scrapings g...

Descripción completa

Detalles Bibliográficos
Autores principales: Morelli, Morgan K., Kloosterboer, Amy, Fulton, Scott A., Furin, Jennifer, Newman, Nicholas, Omar, Ahmed F., Rojas, Laura J., Marshall, Steven H., Yasmin, Mohamad, Bonomo, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Challenging Clinical Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358754/
https://www.ncbi.nlm.nih.gov/pubmed/37166191
http://dx.doi.org/10.1128/aac.00277-23
_version_ 1785075733775777792
author Morelli, Morgan K.
Kloosterboer, Amy
Fulton, Scott A.
Furin, Jennifer
Newman, Nicholas
Omar, Ahmed F.
Rojas, Laura J.
Marshall, Steven H.
Yasmin, Mohamad
Bonomo, Robert A.
author_facet Morelli, Morgan K.
Kloosterboer, Amy
Fulton, Scott A.
Furin, Jennifer
Newman, Nicholas
Omar, Ahmed F.
Rojas, Laura J.
Marshall, Steven H.
Yasmin, Mohamad
Bonomo, Robert A.
author_sort Morelli, Morgan K.
collection PubMed
description Resistant Gram-negative bacteria are a growing concern in the United States, leading to significant morbidity and mortality. We identified a 72-year-old female patient who presented with unilateral vision loss. She was found to have a large corneal ulcer with hypopyon. Culture of corneal scrapings grew extensively drug-resistant Pseudomonas aeruginosa. Treatment involved a combination of systemic and topical antibiotics. Whole genome sequencing revealed the presence of bla(VIM-80), bla(GES-9), and other resistance determinants. This distinctive organism was linked to an over-the-counter artificial tears product.
format Online
Article
Text
id pubmed-10358754
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-103587542023-07-21 Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa Morelli, Morgan K. Kloosterboer, Amy Fulton, Scott A. Furin, Jennifer Newman, Nicholas Omar, Ahmed F. Rojas, Laura J. Marshall, Steven H. Yasmin, Mohamad Bonomo, Robert A. Antimicrob Agents Chemother Challenging Clinical Case Resistant Gram-negative bacteria are a growing concern in the United States, leading to significant morbidity and mortality. We identified a 72-year-old female patient who presented with unilateral vision loss. She was found to have a large corneal ulcer with hypopyon. Culture of corneal scrapings grew extensively drug-resistant Pseudomonas aeruginosa. Treatment involved a combination of systemic and topical antibiotics. Whole genome sequencing revealed the presence of bla(VIM-80), bla(GES-9), and other resistance determinants. This distinctive organism was linked to an over-the-counter artificial tears product. American Society for Microbiology 2023-05-10 /pmc/articles/PMC10358754/ /pubmed/37166191 http://dx.doi.org/10.1128/aac.00277-23 Text en Copyright © 2023 Morelli et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Challenging Clinical Case
Morelli, Morgan K.
Kloosterboer, Amy
Fulton, Scott A.
Furin, Jennifer
Newman, Nicholas
Omar, Ahmed F.
Rojas, Laura J.
Marshall, Steven H.
Yasmin, Mohamad
Bonomo, Robert A.
Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa
title Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa
title_full Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa
title_fullStr Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa
title_full_unstemmed Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa
title_short Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa
title_sort investigating and treating a corneal ulcer due to extensively drug-resistant pseudomonas aeruginosa
topic Challenging Clinical Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358754/
https://www.ncbi.nlm.nih.gov/pubmed/37166191
http://dx.doi.org/10.1128/aac.00277-23
work_keys_str_mv AT morellimorgank investigatingandtreatingacornealulcerduetoextensivelydrugresistantpseudomonasaeruginosa
AT kloosterboeramy investigatingandtreatingacornealulcerduetoextensivelydrugresistantpseudomonasaeruginosa
AT fultonscotta investigatingandtreatingacornealulcerduetoextensivelydrugresistantpseudomonasaeruginosa
AT furinjennifer investigatingandtreatingacornealulcerduetoextensivelydrugresistantpseudomonasaeruginosa
AT newmannicholas investigatingandtreatingacornealulcerduetoextensivelydrugresistantpseudomonasaeruginosa
AT omarahmedf investigatingandtreatingacornealulcerduetoextensivelydrugresistantpseudomonasaeruginosa
AT rojaslauraj investigatingandtreatingacornealulcerduetoextensivelydrugresistantpseudomonasaeruginosa
AT marshallstevenh investigatingandtreatingacornealulcerduetoextensivelydrugresistantpseudomonasaeruginosa
AT yasminmohamad investigatingandtreatingacornealulcerduetoextensivelydrugresistantpseudomonasaeruginosa
AT bonomoroberta investigatingandtreatingacornealulcerduetoextensivelydrugresistantpseudomonasaeruginosa

Ejemplares similares