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Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis

INTRODUCTION: The PI3K/AKT pathway is activated in 43-70% of breast cancer (BC)-patients and promotes the metastatic potential of BC cells by increasing cell proliferation, invasion and radioresistance. Therefore, AKT1-inhibition in combination with radiotherapy might be an effective treatment optio...

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Detalles Bibliográficos
Autores principales:	Kempska, Joanna, Oliveira-Ferrer, Leticia, Grottke, Astrid, Qi, Minyue, Alawi, Malik, Meyer, Felix, Borgmann, Kerstin, Hamester, Fabienne, Eylmann, Kathrin, Rossberg, Maila, Smit, Daniel J., Jücker, Manfred, Laakmann, Elena, Witzel, Isabell, Schmalfeldt, Barbara, Müller, Volkmar, Legler, Karen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358765/ https://www.ncbi.nlm.nih.gov/pubmed/37483521 http://dx.doi.org/10.3389/fonc.2023.1129682

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