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The impact of preoperative total parenteral nutrition on the surgical complications of Crohn’s disease: A retrospective cohort study

BACKGROUND: Crohn’s disease (CD) is associated with malnutrition, an independent risk factor for surgical morbidity and mortality in more than 65% of patients, with a significant impact on disease outcomes. In this single-center retrospective cohort study, we aimed to investigate the impact of total...

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Detalles Bibliográficos
Autores principales: Bin Traiki, Thamer A., Alshammari, Sulaiman A., Aljomah, Nadia A., Alsalouli, Monirah M., Altawil, Esraa S., Abdulla, Maha-Hamadien, Alhassan, Noura S., Alkhayal, Khayal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358801/
https://www.ncbi.nlm.nih.gov/pubmed/36588367
http://dx.doi.org/10.4103/sjg.sjg_425_22
Descripción
Sumario:BACKGROUND: Crohn’s disease (CD) is associated with malnutrition, an independent risk factor for surgical morbidity and mortality in more than 65% of patients, with a significant impact on disease outcomes. In this single-center retrospective cohort study, we aimed to investigate the impact of total parenteral nutrition (TPN) on the surgical outcomes of patients with CD. METHODS: This study included patients with CD who underwent abdominal surgery. We compared patients who received preoperative total parenteral nutrition (TPN group) to those who did not (non-TPN group). Prolonged oral intolerance, albumin level <30 g/L, and body mass index <18.5 were the main indications for TPN. We evaluated postoperative surgical complications in both groups. RESULTS: Between January 2010 and October 2018, 169 eligible patients underwent abdominal surgery. The TPN and non-TPN groups included 40 and 129 patients, respectively. The mean albumin level was significantly lower in the TPN group (P = 0.013). Laparoscopic surgery was performed in 76.9% of the patients, with a conversion rate of 11.6%. Infectious and non-infectious complications developed in 8.9% and 16% of patients, respectively. Surgical complications were comparable between the groups (P >0.05). CONCLUSIONS: Despite oral intake intolerance and severe disease in the TPN group, the surgical complications were comparable between the groups.