Dexamethasone affects human fetal adrenal steroidogenesis and subsequent ACTH response in an ex vivo culture model

INTRODUCTION: Administration of dexamethasone (DEX) has been used experimentally to suppress androgenization of external genitalia in 46,XX fetuses with congenital adrenal hyperplasia. Despite this, the prenatal biological mechanism-of-action of DEX on fetal development is not known. This study aime...

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Detalles Bibliográficos
Autores principales: Melau, Cecilie, Gayete Mor, Berta, Lundgaard Riis, Malene, Nielsen, John E., Dreisler, Eva, Aaboe, Kasper, Tutein Brenøe, Pia, Langhoff Thuesen, Lea, Juul Hare, Kristine, Mitchell, Rod T., Frederiksen, Hanne, Juul, Anders, Jørgensen, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358843/
https://www.ncbi.nlm.nih.gov/pubmed/37484942
http://dx.doi.org/10.3389/fendo.2023.1114211

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