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Subclinical hypothyroidism increases insulin resistance in normoglycemic people

OBJECTIVE: To investigate the effect of simple subclinical hypothyroidism (SCH) and type 2 diabetes mellitus (T2DM) combined with SCH on insulin resistance. DESIGN AND METHODS: A total of 622 people with newly diagnosed T2DM were selected as the study subjects, and 621 normoglycemic people were sele...

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Autores principales: Yang, Wanyu, Jin, Chenye, Wang, Haoyu, Lai, Yaxin, Li, Jiashu, Shan, Zhongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358968/
https://www.ncbi.nlm.nih.gov/pubmed/37484968
http://dx.doi.org/10.3389/fendo.2023.1106968
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author Yang, Wanyu
Jin, Chenye
Wang, Haoyu
Lai, Yaxin
Li, Jiashu
Shan, Zhongyan
author_facet Yang, Wanyu
Jin, Chenye
Wang, Haoyu
Lai, Yaxin
Li, Jiashu
Shan, Zhongyan
author_sort Yang, Wanyu
collection PubMed
description OBJECTIVE: To investigate the effect of simple subclinical hypothyroidism (SCH) and type 2 diabetes mellitus (T2DM) combined with SCH on insulin resistance. DESIGN AND METHODS: A total of 622 people with newly diagnosed T2DM were selected as the study subjects, and 621 normoglycemic people were selected as control subjects. According to the diagnostic criteria of thyroid diseases, the subjects were divided into a normal thyroid function group and a subclinical hypothyroidism group. Both groups received a physical examination, and blood samples were collected. The measurement indexes included FPG, FINS, OGTT2hPG, OGTT2hINS, HbA1c, TC, TG, HDL-C, LDL-C, TSH, FT3 and FT4. HOMA-IR, HOMA-β, and TFQI (thyroid feedback quantile index) were calculated. RESULTS: There was no significant difference in age or sex distribution between the T2DM group and the normoglycemic group (P>0.05). The prevalence of thyroid dysfunction in the T2DM group was significantly higher than that in the normoglycemic group (16.39% vs. 11.27%, P<0.05), and among the different types of thyroid dysfunction, the prevalence of SCH was the highest at 14.95% (P<0.05). There was no significant difference in BMI, waist-hip ratio, blood lipid profile, HOMA-β, and HOMA-IR values between the T2DM with subclinical hypothyroidism group (T2DM+SCH+ group) and the normal thyroid function group (T2DM+SCH- group) (P>0.05). The BMI, waist-hip ratio and HOMA-IR values of the normoglycemic group with subclinical hypothyroidism (T2DM-SCH+ group) were significantly higher than those of the normoglycemic group with normal thyroid function (T2DM-SCH- group) (P<0.05), and there were no significant differences between the T2DM+SCH- and T2DM+SCH+ groups (P>0.05). HOMA-β values were significantly higher in the T2DM-SCH+ group than in the T2DM-SCH-, T2DM+SCH- and T2DM+SCH+ groups (P<0.05). As the TFQI value increased, the body weight, waist-hip ratio, diastolic blood pressure, FPG, OGTT2hPG and HbA1c values gradually increased in the T2DM group and normoglycemic group (P<0.05). HDL-C, FINS, OGTT2hINS and HOMA-β values gradually decreased (P<0.05). CONCLUSION: Subclinical hypothyroidism only increases insulin resistance in normoglycemic people. As the sensitivity of the central thyroid decreases, the risk of developing diabetes increases.
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spelling pubmed-103589682023-07-21 Subclinical hypothyroidism increases insulin resistance in normoglycemic people Yang, Wanyu Jin, Chenye Wang, Haoyu Lai, Yaxin Li, Jiashu Shan, Zhongyan Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: To investigate the effect of simple subclinical hypothyroidism (SCH) and type 2 diabetes mellitus (T2DM) combined with SCH on insulin resistance. DESIGN AND METHODS: A total of 622 people with newly diagnosed T2DM were selected as the study subjects, and 621 normoglycemic people were selected as control subjects. According to the diagnostic criteria of thyroid diseases, the subjects were divided into a normal thyroid function group and a subclinical hypothyroidism group. Both groups received a physical examination, and blood samples were collected. The measurement indexes included FPG, FINS, OGTT2hPG, OGTT2hINS, HbA1c, TC, TG, HDL-C, LDL-C, TSH, FT3 and FT4. HOMA-IR, HOMA-β, and TFQI (thyroid feedback quantile index) were calculated. RESULTS: There was no significant difference in age or sex distribution between the T2DM group and the normoglycemic group (P>0.05). The prevalence of thyroid dysfunction in the T2DM group was significantly higher than that in the normoglycemic group (16.39% vs. 11.27%, P<0.05), and among the different types of thyroid dysfunction, the prevalence of SCH was the highest at 14.95% (P<0.05). There was no significant difference in BMI, waist-hip ratio, blood lipid profile, HOMA-β, and HOMA-IR values between the T2DM with subclinical hypothyroidism group (T2DM+SCH+ group) and the normal thyroid function group (T2DM+SCH- group) (P>0.05). The BMI, waist-hip ratio and HOMA-IR values of the normoglycemic group with subclinical hypothyroidism (T2DM-SCH+ group) were significantly higher than those of the normoglycemic group with normal thyroid function (T2DM-SCH- group) (P<0.05), and there were no significant differences between the T2DM+SCH- and T2DM+SCH+ groups (P>0.05). HOMA-β values were significantly higher in the T2DM-SCH+ group than in the T2DM-SCH-, T2DM+SCH- and T2DM+SCH+ groups (P<0.05). As the TFQI value increased, the body weight, waist-hip ratio, diastolic blood pressure, FPG, OGTT2hPG and HbA1c values gradually increased in the T2DM group and normoglycemic group (P<0.05). HDL-C, FINS, OGTT2hINS and HOMA-β values gradually decreased (P<0.05). CONCLUSION: Subclinical hypothyroidism only increases insulin resistance in normoglycemic people. As the sensitivity of the central thyroid decreases, the risk of developing diabetes increases. Frontiers Media S.A. 2023-07-06 /pmc/articles/PMC10358968/ /pubmed/37484968 http://dx.doi.org/10.3389/fendo.2023.1106968 Text en Copyright © 2023 Yang, Jin, Wang, Lai, Li and Shan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yang, Wanyu
Jin, Chenye
Wang, Haoyu
Lai, Yaxin
Li, Jiashu
Shan, Zhongyan
Subclinical hypothyroidism increases insulin resistance in normoglycemic people
title Subclinical hypothyroidism increases insulin resistance in normoglycemic people
title_full Subclinical hypothyroidism increases insulin resistance in normoglycemic people
title_fullStr Subclinical hypothyroidism increases insulin resistance in normoglycemic people
title_full_unstemmed Subclinical hypothyroidism increases insulin resistance in normoglycemic people
title_short Subclinical hypothyroidism increases insulin resistance in normoglycemic people
title_sort subclinical hypothyroidism increases insulin resistance in normoglycemic people
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358968/
https://www.ncbi.nlm.nih.gov/pubmed/37484968
http://dx.doi.org/10.3389/fendo.2023.1106968
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