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Intervertebral disc degeneration—Current therapeutic options and challenges

Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's declining function and the development of pain, it may affect one's physical health, mental health, and socioeconomic status. Most of the intervertebral disc degeneration (IVDD) therapies today focu...

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Detalles Bibliográficos
Autores principales: Samanta, Ankita, Lufkin, Thomas, Kraus, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359191/
https://www.ncbi.nlm.nih.gov/pubmed/37483952
http://dx.doi.org/10.3389/fpubh.2023.1156749
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author Samanta, Ankita
Lufkin, Thomas
Kraus, Petra
author_facet Samanta, Ankita
Lufkin, Thomas
Kraus, Petra
author_sort Samanta, Ankita
collection PubMed
description Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's declining function and the development of pain, it may affect one's physical health, mental health, and socioeconomic status. Most of the intervertebral disc degeneration (IVDD) therapies today focus on the symptoms of low back pain rather than the underlying etiology or mechanical function of the disc. The deteriorated disc is typically not restored by conservative or surgical therapies that largely focus on correcting symptoms and structural abnormalities. To enhance the clinical outcome and the quality of life of a patient, several therapeutic modalities have been created. In this review, we discuss genetic and environmental causes of IVDD and describe promising modern endogenous and exogenous therapeutic approaches including their applicability and relevance to the degeneration process.
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spelling pubmed-103591912023-07-22 Intervertebral disc degeneration—Current therapeutic options and challenges Samanta, Ankita Lufkin, Thomas Kraus, Petra Front Public Health Public Health Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's declining function and the development of pain, it may affect one's physical health, mental health, and socioeconomic status. Most of the intervertebral disc degeneration (IVDD) therapies today focus on the symptoms of low back pain rather than the underlying etiology or mechanical function of the disc. The deteriorated disc is typically not restored by conservative or surgical therapies that largely focus on correcting symptoms and structural abnormalities. To enhance the clinical outcome and the quality of life of a patient, several therapeutic modalities have been created. In this review, we discuss genetic and environmental causes of IVDD and describe promising modern endogenous and exogenous therapeutic approaches including their applicability and relevance to the degeneration process. Frontiers Media S.A. 2023-07-06 /pmc/articles/PMC10359191/ /pubmed/37483952 http://dx.doi.org/10.3389/fpubh.2023.1156749 Text en Copyright © 2023 Samanta, Lufkin and Kraus. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Samanta, Ankita
Lufkin, Thomas
Kraus, Petra
Intervertebral disc degeneration—Current therapeutic options and challenges
title Intervertebral disc degeneration—Current therapeutic options and challenges
title_full Intervertebral disc degeneration—Current therapeutic options and challenges
title_fullStr Intervertebral disc degeneration—Current therapeutic options and challenges
title_full_unstemmed Intervertebral disc degeneration—Current therapeutic options and challenges
title_short Intervertebral disc degeneration—Current therapeutic options and challenges
title_sort intervertebral disc degeneration—current therapeutic options and challenges
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359191/
https://www.ncbi.nlm.nih.gov/pubmed/37483952
http://dx.doi.org/10.3389/fpubh.2023.1156749
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