Cargando…

Aryl-functionalised α,α′-Trehalose 6,6′-Glycolipid Induces Mincle-independent Pyroptotic Cell Death

α,α′-Trehalose 6,6′-glycolipids have long been known for their immunostimulatory properties. The adjuvanticity of α,α′-trehalose 6,6′-glycolipids is mediated by signalling through the macrophage inducible C-type lectin (Mincle) and the induction of an inflammatory response. Herein, we present an ary...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kodar, Kristel, Dangerfield, Emma M., Foster, Amy J., Forsythe, Devlin, Ishizuka, Shigenari, McConnell, Melanie J., Yamasaki, Sho, Timmer, Mattie S. M., Stocker, Bridget L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359228/ https://www.ncbi.nlm.nih.gov/pubmed/37140682 http://dx.doi.org/10.1007/s10753-023-01814-5

Ejemplares similares

Water-soluble trehalose glycolipids show superior Mincle binding and signaling but impaired phagocytosis and IL-1β production
por: Manthrirathna, M. A. Thathsaranie P., et al.
Publicado: (2022)

The Mincle ligand trehalose dibehenate differentially modulates M1‐like and M2‐like macrophage phenotype and function via Syk signaling
por: Kodar, Kristel, et al.
Publicado: (2017)

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
por: Ishikawa, Eri, et al.
Publicado: (2009)

The trehalose glycolipid C18Brar promotes antibody and T-cell immune responses to Mannheimia haemolytica and Mycoplasma ovipneumoniae whole cell antigens in sheep
por: Gupta, Sandeep K., et al.
Publicado: (2023)

Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo
por: Huber, Alexandra, et al.
Publicado: (2016)

Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle
por: Feinberg, Hadar, et al.
Publicado: (2016)

Methyl 6-azido-6-deoxy-α-d-galactoside
por: Cheng, Janice M. H., et al.
Publicado: (2011)

Methyl 6-deoxy-6-iodo-α-d-galactoside
por: Gulab, Shivali A., et al.
Publicado: (2010)

PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand
por: Ishizuka, Shigenari, et al.
Publicado: (2023)

Mechanism for Recognition of an Unusual Mycobacterial Glycolipid by the Macrophage Receptor Mincle
por: Feinberg, Hadar, et al.
Publicado: (2013)

Defining the conformation of human mincle that interacts with mycobacterial trehalose dimycolate
por: Jégouzo, Sabine A F, et al.
Publicado: (2014)

Evaluation of anti α-d-Glcp-(1→4)-α-d-Glcp (GAGA4) IgM antibodies as a biomarker for multiple sclerosis
por: Braganza, Chriselle D., et al.
Publicado: (2018)

Species-Specific Structural Requirements of Alpha-Branched Trehalose Diester Mincle Agonists
por: Smith, Alyson J., et al.
Publicado: (2019)

Interaction of Glycolipids with the Macrophage Surface Receptor Mincle – a Systematic Molecular Dynamics Study
por: Söldner, Christian A., et al.
Publicado: (2018)

High Secretion of Interleukin-6 and Increased MINCLE Receptor Expression Upon Exposure to Mycobacterial Cord Factor Analog Trehalose-6, 6-Dibehenate (TDB) in Patients with Takayasu Arteritis
por: Gupta, Nikhil, et al.
Publicado: (2018)

Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway
por: Lee, Wook-Bin, et al.
Publicado: (2012)

Orthogonal functionalisation of α-helix mimetics
por: Barnard, Anna, et al.
Publicado: (2014)

Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle
por: Reijneveld, Josephine F., et al.
Publicado: (2021)

C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia
por: Behler-Janbeck, Friederike, et al.
Publicado: (2016)

Pyroptotic and non‐pyroptotic effector functions of caspase‐11
por: Abu Khweek, Arwa, et al.
Publicado: (2020)

Protecting-Group-Free Synthesis of 2-Deoxy-Aza-Sugars
por: Dangerfield, Emma Marie, et al.
Publicado: (2009)

Mouse Mincle: Characterization as a Model for Human Mincle and Evolutionary Implications
por: Rambaruth, Neela D. S., et al.
Publicado: (2015)

An easy α-glycosylation methodology for the synthesis and stereochemistry of mycoplasma α-glycolipid antigens
por: Nishida, Yoshihiro, et al.
Publicado: (2012)

Monocytes Elicit a Neutrophil-Independent Th1/Th17 Response Upon Immunization With a Mincle-Dependent Glycolipid Adjuvant
por: Desel, Christiane, et al.
Publicado: (2022)

α‐Functionalisation of Ketones Through Metal‐Free Electrophilic Activation
por: Zawodny, Wojciech, et al.
Publicado: (2020)

Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling
por: Patin, Emmanuel C., et al.
Publicado: (2017)

Mycobacterial glycolipid Di-O-acyl trehalose promotes a tolerogenic profile in dendritic cells
por: Magallanes-Puebla, Alejandro, et al.
Publicado: (2018)

Mycobacterial glycolipids di-O-acylated trehalose and tri-O-acylated trehalose downregulate inducible nitric oxide synthase and nitric oxide production in macrophages
por: Espinosa-Cueto, Patricia, et al.
Publicado: (2015)

Modified α,α′-trehalose and d-glucose: green monomers for the synthesis of vinyl copolymers
por: Papacchini, A., et al.
Publicado: (2018)

Activation of Invariant NKT Cells with Glycolipid Ligand α-Galactosylceramide Ameliorates Glucose-6-Phosphate Isomerase Peptide-Induced Arthritis
por: Horikoshi, Masanobu, et al.
Publicado: (2012)

Altered (neo-) lacto series glycolipid biosynthesis impairs α2-6 sialylation on N-glycoproteins in ovarian cancer cells
por: Alam, Shahidul, et al.
Publicado: (2017)

Statins as anti-pyroptotic agents
por: Khalifeh, Masoomeh, et al.
Publicado: (2021)

The NKT cell TCR repertoire can accommodate structural modifications to the lipid and orientation of the terminal carbohydrate of iGb3
por: Cameron, Garth, et al.
Publicado: (2022)

Genome-Wide Identification and Analysis of Stress Response of Trehalose-6-Phosphate Synthase and Trehalose-6-Phosphate Phosphatase Genes in Quinoa
por: Wang, Xiaoting, et al.
Publicado: (2023)

Synthesis of isobemisiose, neosartose, and fischerose: three α-1,6-linked trehalose-based oligosaccharides identified from Neosartorya fischeri
por: Kuenstner, E. J., et al.
Publicado: (2020)

Characterization of a Glycolipid Synthase Producing α-Galactosylceramide in Bacteroides fragilis
por: Caballé, Marc, et al.
Publicado: (2022)

Synthesis of a Versatile Building Block for the Preparation of 6-N-Derivatized α-Galactosyl Ceramides: Rapid Access to Biologically Active Glycolipids
por: Jervis, Peter J., et al.
Publicado: (2010)

Highly selective α-aryloxyalkyl C–H functionalisation of aryl alkyl ethers
por: Bell, Jonathan D., et al.
Publicado: (2022)

Salt Stress Response of Sulfolobus acidocaldarius Involves Complex Trehalose Metabolism Utilizing a Novel Trehalose-6-Phosphate Synthase (TPS)/Trehalose-6-Phosphate Phosphatase (TPP) Pathway
por: Stracke, Christina, et al.
Publicado: (2020)

Axl Deficiency Promotes the Neuroinvasion of Japanese Encephalitis Virus by Enhancing IL-1α Production from Pyroptotic Macrophages
por: Wang, Zhao-Yang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_edq0pelhf23gcphi9s832h8ij7