Age-related self-DNA accumulation may accelerate arthritis in rats and in human rheumatoid arthritis

The incidence of rheumatoid arthritis (RA) is increasing with age. DNA fragments is known to accumulate in certain autoimmune diseases, but the mechanistic relationship among ageing, DNA fragments and RA pathogenesis remain unexplored. Here we show that the accumulation of DNA fragments, increasing...

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Detalles Bibliográficos
Autores principales: Luo, Wei-Dan, Wang, Yu-Ping, Lv, Jun, Liu, Yong, Qu, Yuan-Qing, Xu, Xiong-Fei, Yang, Li-Jun, Lin, Zi-Cong, Wang, Lin-Na, Chen, Rui-Hong, Yang, Jiu-Jie, Zeng, Ya-Ling, Zhang, Rui-Long, Huang, Bai-Xiong, Yun, Xiao-Yun, Wang, Xuan-Ying, Song, Lin-Lin, Wu, Jian-Hui, Wang, Xing-Xia, Chen, Xi, Zhang, Wei, Wang, Hui-Miao, Qu, Li-Qun, Liu, Meng-Han, Liu, Liang, Law, Betty Yuen Kwan, Wong, Vincent Kam Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359253/
https://www.ncbi.nlm.nih.gov/pubmed/37474626
http://dx.doi.org/10.1038/s41467-023-40113-3

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