Structures of channelrhodopsin paralogs in peptidiscs explain their contrasting K(+) and Na(+) selectivities

Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) is a light-gated channel used for optogenetic silencing of mammalian neurons. It selects K(+) over Na(+) in the absence of the canonical tetrameric K(+) selectivity filter found universally in voltage- and ligand-gated channels. The ge...

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Detalles Bibliográficos
Autores principales: Morizumi, Takefumi, Kim, Kyumhyuk, Li, Hai, Govorunova, Elena G., Sineshchekov, Oleg A., Wang, Yumei, Zheng, Lei, Bertalan, Éva, Bondar, Ana-Nicoleta, Askari, Azam, Brown, Leonid S., Spudich, John L., Ernst, Oliver P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359266/
https://www.ncbi.nlm.nih.gov/pubmed/37474513
http://dx.doi.org/10.1038/s41467-023-40041-2

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