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Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques
The value of one’s own reward is affected by the reward of others, serving as a source for envy. However, it is not known which neural circuits mediate such socially subjective value modulation. Here, we chemogenetically dissected the circuit from the medial prefrontal cortex (MPFC) to the lateral h...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359292/ https://www.ncbi.nlm.nih.gov/pubmed/37474519 http://dx.doi.org/10.1038/s41467-023-40143-x |
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author | Noritake, Atsushi Ninomiya, Taihei Kobayashi, Kenta Isoda, Masaki |
author_facet | Noritake, Atsushi Ninomiya, Taihei Kobayashi, Kenta Isoda, Masaki |
author_sort | Noritake, Atsushi |
collection | PubMed |
description | The value of one’s own reward is affected by the reward of others, serving as a source for envy. However, it is not known which neural circuits mediate such socially subjective value modulation. Here, we chemogenetically dissected the circuit from the medial prefrontal cortex (MPFC) to the lateral hypothalamus (LH) while male macaques were presented with visual stimuli that concurrently signaled the prospects of one’s own and others’ rewards. We found that functional disconnection between the MPFC and LH rendered animals significantly less susceptible to others’ but not one’s own reward prospects. In parallel with this behavioral change, inter-areal coordination, as indexed by coherence and Granger causality, decreased primarily in the delta and theta bands. These findings demonstrate that the MPFC-to-LH circuit plays a crucial role in carrying information about upcoming other-rewards for subjective reward valuation in social contexts. |
format | Online Article Text |
id | pubmed-10359292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103592922023-07-22 Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques Noritake, Atsushi Ninomiya, Taihei Kobayashi, Kenta Isoda, Masaki Nat Commun Article The value of one’s own reward is affected by the reward of others, serving as a source for envy. However, it is not known which neural circuits mediate such socially subjective value modulation. Here, we chemogenetically dissected the circuit from the medial prefrontal cortex (MPFC) to the lateral hypothalamus (LH) while male macaques were presented with visual stimuli that concurrently signaled the prospects of one’s own and others’ rewards. We found that functional disconnection between the MPFC and LH rendered animals significantly less susceptible to others’ but not one’s own reward prospects. In parallel with this behavioral change, inter-areal coordination, as indexed by coherence and Granger causality, decreased primarily in the delta and theta bands. These findings demonstrate that the MPFC-to-LH circuit plays a crucial role in carrying information about upcoming other-rewards for subjective reward valuation in social contexts. Nature Publishing Group UK 2023-07-20 /pmc/articles/PMC10359292/ /pubmed/37474519 http://dx.doi.org/10.1038/s41467-023-40143-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Noritake, Atsushi Ninomiya, Taihei Kobayashi, Kenta Isoda, Masaki Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
title | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
title_full | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
title_fullStr | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
title_full_unstemmed | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
title_short | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
title_sort | chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359292/ https://www.ncbi.nlm.nih.gov/pubmed/37474519 http://dx.doi.org/10.1038/s41467-023-40143-x |
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