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Insertion sequence transposition inactivates CRISPR-Cas immunity

CRISPR-Cas immunity systems safeguard prokaryotic genomes by inhibiting the invasion of mobile genetic elements. Here, we screened prokaryotic genomic sequences and identified multiple natural transpositions of insertion sequences (ISs) into cas genes, thus inactivating CRISPR-Cas defenses. We then...

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Detalles Bibliográficos
Autores principales:	Sheng, Yong, Wang, Hengyu, Ou, Yixin, Wu, Yingying, Ding, Wei, Tao, Meifeng, Lin, Shuangjun, Deng, Zixin, Bai, Linquan, Kang, Qianjin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359306/ https://www.ncbi.nlm.nih.gov/pubmed/37474569 http://dx.doi.org/10.1038/s41467-023-39964-7

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