IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation

The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1. UBE2L3, a ubiquitin conjugating enzyme, promotes pro-IL-1β ubiquitylation and...

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Detalles Bibliográficos
Autores principales: Mishra, Vishwas, Crespo-Puig, Anna, McCarthy, Callum, Masonou, Tereza, Glegola-Madejska, Izabela, Dejoux, Alice, Dow, Gabriella, Eldridge, Matthew J. G., Marinelli, Luciano H., Meng, Meihan, Wang, Shijie, Bennison, Daniel J., Morrison, Rebecca, Shenoy, Avinash R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359330/
https://www.ncbi.nlm.nih.gov/pubmed/37474493
http://dx.doi.org/10.1038/s41467-023-40054-x

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