Camptothecin Sensitizes Hepatocellular Carcinoma Cells to Sorafenib- Induced Ferroptosis Via Suppression of Nrf2

Sorafenib is a potent inducer of ferroptosis used to manage hepatocellular carcinoma (HCC). The ferroptosis induced by sorafenib activates the p62–Keap1–Nrf2 pathway. Abnormal activation of Nrf2 reduces sorafenib’s efficiency and ferroptosis action and induces sorafenib’s resistance. Consequently, o...

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Detalles Bibliográficos
Autores principales: Elkateb, Ahmed S., Nofal, Shahira, Ali, Sahar A., Atya, Hanaa B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359394/
https://www.ncbi.nlm.nih.gov/pubmed/37171695
http://dx.doi.org/10.1007/s10753-023-01823-4

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