Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry

The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates incorporation of SERINCs via binding to intracellular loop 4 (ICL4). Here, we determine cryoEM maps of full-length human SE...

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Detalles Bibliográficos
Autores principales: Leonhardt, Susan A., Purdy, Michael D., Grover, Jonathan R., Yang, Ziwei, Poulos, Sandra, McIntire, William E., Tatham, Elizabeth A., Erramilli, Satchal K., Nosol, Kamil, Lai, Kin Kui, Ding, Shilei, Lu, Maolin, Uchil, Pradeep D., Finzi, Andrés, Rein, Alan, Kossiakoff, Anthony A., Mothes, Walther, Yeager, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359404/
https://www.ncbi.nlm.nih.gov/pubmed/37474505
http://dx.doi.org/10.1038/s41467-023-39262-2

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