Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1

Mesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been extensively investigated for their therapeutic potential in treating inflammatory disorders. However, the mechanisms underlying the immunosuppressive function of MSCs are not fully understood, hindering the developm...

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Detalles Bibliográficos
Autores principales: Gao, Yuchen, Chi, Ying, Chen, Yunfei, Wang, Wentian, Li, Huiyuan, Zheng, Wenting, Zhu, Ping, An, Jinying, Duan, Yanan, Sun, Ting, Liu, Xiaofan, Xue, Feng, Liu, Wei, Fu, Rongfeng, Han, Zhibo, Zhang, Yingchi, Yang, Renchi, Cheng, Tao, Wei, Jun, Zhang, Lei, Zhang, Xiaomin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359415/
https://www.ncbi.nlm.nih.gov/pubmed/37474525
http://dx.doi.org/10.1038/s41467-023-39958-5

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