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Pharmacokinetic–pharmacodynamic modeling of maintenance therapy for childhood acute lymphoblastic leukemia

In the treatment of childhood acute lymphoblastic leukemia (ALL), current protocols combine initial high-dose multiagent chemotherapy with prolonged oral therapy with 6-mercaptopurine (6MP) and low-dose methotrexate (MTX) maintenance therapy. Decades of research on ALL treatment have resulted in sur...

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Detalles Bibliográficos
Autores principales:	Gebhard, Anna, Lilienthal, Patrick, Metzler, Markus, Rauh, Manfred, Sager, Sebastian, Schmiegelow, Kjeld, Toksvang, Linea Natalie, Zierk, Jakob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359452/ https://www.ncbi.nlm.nih.gov/pubmed/37474565 http://dx.doi.org/10.1038/s41598-023-38414-0

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