Mutational and structural analyses of UdgX: insights into the active site pocket architecture and its evolution

UdgX excises uracil from uracil-containing DNA to concurrently form a covalent bond with the resulting AP-DNA. Structurally, UdgX is highly similar to family-4 UDGs (F4-UDGs). However, UdgX is unique in possessing a flexible R-loop ((105)KRRIH(109)). Among the class-defining motifs, while its motif...

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Detalles Bibliográficos
Autores principales: Aroli, Shashanka, Woo, Eui-Jeon, Gopal, Balasubramanian, Varshney, Umesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359453/
https://www.ncbi.nlm.nih.gov/pubmed/37283083
http://dx.doi.org/10.1093/nar/gkad486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359453/
https://www.ncbi.nlm.nih.gov/pubmed/37283083
http://dx.doi.org/10.1093/nar/gkad486

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