Structural basis of the T4 bacteriophage primosome assembly and primer synthesis

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The T4 bacteriophage gp41 helicase and gp61 primase assemble into a primosome to couple DNA unwinding with RNA primer synthesis for DNA replication. How the primosome is assembled and how the primer length is defined are unclear. Here we report a series of cryo-EM structures of T4 primosome assembly...

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Detalles Bibliográficos
Autores principales: Feng, Xiang, Spiering, Michelle M., de Luna Almeida Santos, Ruda, Benkovic, Stephen J., Li, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359460/
https://www.ncbi.nlm.nih.gov/pubmed/37474605
http://dx.doi.org/10.1038/s41467-023-40106-2

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