Identification of a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1

Replication Protein A (RPA) is a broadly conserved complex comprised of the RPA1, 2 and 3 subunits. RPA protects the exposed single-stranded DNA (ssDNA) during DNA replication and repair. Using structural modeling, we discover an inhibitor, JC-229, that targets RPA1 in Trypanosoma brucei, the causat...

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Detalles Bibliográficos
Autores principales: Mukherjee, Aditi, Hossain, Zakir, Erben, Esteban, Ma, Shuai, Choi, Jun Yong, Kim, Hee-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359466/
https://www.ncbi.nlm.nih.gov/pubmed/37474515
http://dx.doi.org/10.1038/s41467-023-39839-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359466/
https://www.ncbi.nlm.nih.gov/pubmed/37474515
http://dx.doi.org/10.1038/s41467-023-39839-x

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