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Identification and characterization of aptameric inhibitors of human neutrophil elastase

Human neutrophil elastase (HNE) plays a pivotal role in innate immunity, inflammation, and tissue remodeling. Aberrant proteolytic activity of HNE contributes to organ destruction in various chronic inflammatory diseases including emphysema, asthma, and cystic fibrosis. Therefore, elastase inhibitor...

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Detalles Bibliográficos
Autores principales:	Malicki, Stanisław, Książek, Mirosław, Sochaj Gregorczyk, Alicja, Kamińska, Marta, Golda, Anna, Chruścicka, Barbara, Mizgalska, Danuta, Potempa, Jan, Marti, Hans-Peter, Kozieł, Joanna, Wieczorek, Maciej, Pieczykolan, Jerzy, Mydel, Piotr, Dubin, Grzegorz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359491/ https://www.ncbi.nlm.nih.gov/pubmed/37286041 http://dx.doi.org/10.1016/j.jbc.2023.104889

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