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Targeting m(6)A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer

OBJECTIVE: The role of N(6)-methyladenosine (m(6)A) in tumour immune microenvironment (TIME) remains understudied. Here, we elucidate function and mechanism of YTH N(6)-methyladenosine RNA binding protein 1 (YTHDF1) in colorectal cancer (CRC) TIME. DESIGN: Clinical significance of YTHDF1 was assesse...

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Detalles Bibliográficos
Autores principales:	Bao, Yi, Zhai, Jianning, Chen, Huarong, Wong, Chi Chun, Liang, Cong, Ding, Yanqiang, Huang, Dan, Gou, Hongyan, Chen, Danyu, Pan, Yasi, Kang, Wei, To, Ka Fai, Yu, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Colon
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359538/ https://www.ncbi.nlm.nih.gov/pubmed/36717220 http://dx.doi.org/10.1136/gutjnl-2022-328845

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