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Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK)

BACKGROUND: The imposition of restrictions on social mixing early in the COVID-19 pandemic was followed by a reduction in asthma exacerbations in multiple settings internationally. Temporal trends in social mixing, incident acute respiratory infections (ARI) and asthma exacerbations following relaxa...

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Autores principales: Tydeman, Florence, Pfeffer, Paul E, Vivaldi, Giulia, Holt, Hayley, Talaei, Mohammad, Jolliffe, David, Davies, Gwyneth, Lyons, Ronan A, Griffiths, Christopher, Kee, Frank, Sheikh, Aziz, Shaheen, Seif O, Martineau, Adrian R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359556/
https://www.ncbi.nlm.nih.gov/pubmed/36423925
http://dx.doi.org/10.1136/thorax-2022-219591
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author Tydeman, Florence
Pfeffer, Paul E
Vivaldi, Giulia
Holt, Hayley
Talaei, Mohammad
Jolliffe, David
Davies, Gwyneth
Lyons, Ronan A
Griffiths, Christopher
Kee, Frank
Sheikh, Aziz
Shaheen, Seif O
Martineau, Adrian R
author_facet Tydeman, Florence
Pfeffer, Paul E
Vivaldi, Giulia
Holt, Hayley
Talaei, Mohammad
Jolliffe, David
Davies, Gwyneth
Lyons, Ronan A
Griffiths, Christopher
Kee, Frank
Sheikh, Aziz
Shaheen, Seif O
Martineau, Adrian R
author_sort Tydeman, Florence
collection PubMed
description BACKGROUND: The imposition of restrictions on social mixing early in the COVID-19 pandemic was followed by a reduction in asthma exacerbations in multiple settings internationally. Temporal trends in social mixing, incident acute respiratory infections (ARI) and asthma exacerbations following relaxation of COVID-19 restrictions have not yet been described. METHODS: We conducted a population-based longitudinal study in 2312 UK adults with asthma between November 2020 and April 2022. Details of face covering use, social mixing, incident ARI and severe asthma exacerbations were collected via monthly online questionnaires. Temporal changes in these parameters were visualised using Poisson generalised additive models. Multilevel logistic regression was used to test for associations between incident ARI and risk of asthma exacerbations, adjusting for potential confounders. RESULTS: Relaxation of COVID-19 restrictions from April 2021 coincided with reduced face covering use (p<0.001), increased frequency of indoor visits to public places and other households (p<0.001) and rising incidence of COVID-19 (p<0.001), non-COVID-19 ARI (p<0.001) and severe asthma exacerbations (p=0.007). Incident non-COVID-19 ARI associated independently with increased risk of asthma exacerbation (adjusted OR 5.75, 95% CI 4.75 to 6.97) as did incident COVID-19, both prior to emergence of the omicron variant of SARS-CoV-2 (5.89, 3.45 to 10.04) and subsequently (5.69, 3.89 to 8.31). CONCLUSIONS: Relaxation of COVID-19 restrictions coincided with decreased face covering use, increased social mixing and a rebound in ARI and asthma exacerbations. Associations between incident ARI and risk of severe asthma exacerbation were similar for non-COVID-19 ARI and COVID-19, both before and after emergence of the SARS-CoV-2 omicron variant. STUDY REGISTRATION NUMBER: NCT04330599.
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spelling pubmed-103595562023-07-22 Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK) Tydeman, Florence Pfeffer, Paul E Vivaldi, Giulia Holt, Hayley Talaei, Mohammad Jolliffe, David Davies, Gwyneth Lyons, Ronan A Griffiths, Christopher Kee, Frank Sheikh, Aziz Shaheen, Seif O Martineau, Adrian R Thorax Asthma BACKGROUND: The imposition of restrictions on social mixing early in the COVID-19 pandemic was followed by a reduction in asthma exacerbations in multiple settings internationally. Temporal trends in social mixing, incident acute respiratory infections (ARI) and asthma exacerbations following relaxation of COVID-19 restrictions have not yet been described. METHODS: We conducted a population-based longitudinal study in 2312 UK adults with asthma between November 2020 and April 2022. Details of face covering use, social mixing, incident ARI and severe asthma exacerbations were collected via monthly online questionnaires. Temporal changes in these parameters were visualised using Poisson generalised additive models. Multilevel logistic regression was used to test for associations between incident ARI and risk of asthma exacerbations, adjusting for potential confounders. RESULTS: Relaxation of COVID-19 restrictions from April 2021 coincided with reduced face covering use (p<0.001), increased frequency of indoor visits to public places and other households (p<0.001) and rising incidence of COVID-19 (p<0.001), non-COVID-19 ARI (p<0.001) and severe asthma exacerbations (p=0.007). Incident non-COVID-19 ARI associated independently with increased risk of asthma exacerbation (adjusted OR 5.75, 95% CI 4.75 to 6.97) as did incident COVID-19, both prior to emergence of the omicron variant of SARS-CoV-2 (5.89, 3.45 to 10.04) and subsequently (5.69, 3.89 to 8.31). CONCLUSIONS: Relaxation of COVID-19 restrictions coincided with decreased face covering use, increased social mixing and a rebound in ARI and asthma exacerbations. Associations between incident ARI and risk of severe asthma exacerbation were similar for non-COVID-19 ARI and COVID-19, both before and after emergence of the SARS-CoV-2 omicron variant. STUDY REGISTRATION NUMBER: NCT04330599. BMJ Publishing Group 2023-08 2022-11-23 /pmc/articles/PMC10359556/ /pubmed/36423925 http://dx.doi.org/10.1136/thorax-2022-219591 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Asthma
Tydeman, Florence
Pfeffer, Paul E
Vivaldi, Giulia
Holt, Hayley
Talaei, Mohammad
Jolliffe, David
Davies, Gwyneth
Lyons, Ronan A
Griffiths, Christopher
Kee, Frank
Sheikh, Aziz
Shaheen, Seif O
Martineau, Adrian R
Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK)
title Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK)
title_full Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK)
title_fullStr Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK)
title_full_unstemmed Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK)
title_short Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK)
title_sort rebound in asthma exacerbations following relaxation of covid-19 restrictions: a longitudinal population-based study (covidence uk)
topic Asthma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359556/
https://www.ncbi.nlm.nih.gov/pubmed/36423925
http://dx.doi.org/10.1136/thorax-2022-219591
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