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Psychopathology in mothers of children with pathogenic Copy Number Variants
BACKGROUND: Caring for children with pathogenic neurodevelopmental Copy Number Variants (CNVs) (ie, deletions and duplications of genetic material) can place a considerable burden on parents and their quality of life. Our study is the first to examine the frequency of psychiatric diagnoses in mother...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359584/ https://www.ncbi.nlm.nih.gov/pubmed/36446581 http://dx.doi.org/10.1136/jmg-2022-108752 |
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author | Niarchou, Maria Cunningham, Adam C. Chawner, Samuel J. R. A. Moulding, Hayley Sopp, Matthew Hall, Jeremy Owen, Michael J. van den Bree, Marianne B.M. |
author_facet | Niarchou, Maria Cunningham, Adam C. Chawner, Samuel J. R. A. Moulding, Hayley Sopp, Matthew Hall, Jeremy Owen, Michael J. van den Bree, Marianne B.M. |
author_sort | Niarchou, Maria |
collection | PubMed |
description | BACKGROUND: Caring for children with pathogenic neurodevelopmental Copy Number Variants (CNVs) (ie, deletions and duplications of genetic material) can place a considerable burden on parents and their quality of life. Our study is the first to examine the frequency of psychiatric diagnoses in mothers of children with CNVs compared with the frequency of psychiatric problems in age-matched mothers from a large community study. METHODS: Case–control study. 268 mothers of children with a CNV diagnosed in a medical genetics clinic and 2680 age-matched mothers taking part in the Avon Longitudinal Study of Parents and Children study. RESULTS: Mothers of children with CNVs reported higher frequency of depression, anorexia, bulimia, alcohol abuse and drug addiction problems compared with the age-matched mothers from the community sample. Focusing on psychiatric problems arising immediately after the birth of the index child, we found that the levels of depression symptoms were similar between the two groups (48% in mothers of children with CNVs vs 44% in mothers of the community sample, p=0.43), but mothers of children with CNVs had higher frequency of anxiety symptoms (55%) compared with mothers from the community sample (30%, p=0.03). CONCLUSION: Our study highlights the need for healthcare providers to devise treatment plans that not only focus on meeting the child’s needs but also assess and, if needed, address the mental health needs of the parent. |
format | Online Article Text |
id | pubmed-10359584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-103595842023-07-22 Psychopathology in mothers of children with pathogenic Copy Number Variants Niarchou, Maria Cunningham, Adam C. Chawner, Samuel J. R. A. Moulding, Hayley Sopp, Matthew Hall, Jeremy Owen, Michael J. van den Bree, Marianne B.M. J Med Genet Copy-Number Variation BACKGROUND: Caring for children with pathogenic neurodevelopmental Copy Number Variants (CNVs) (ie, deletions and duplications of genetic material) can place a considerable burden on parents and their quality of life. Our study is the first to examine the frequency of psychiatric diagnoses in mothers of children with CNVs compared with the frequency of psychiatric problems in age-matched mothers from a large community study. METHODS: Case–control study. 268 mothers of children with a CNV diagnosed in a medical genetics clinic and 2680 age-matched mothers taking part in the Avon Longitudinal Study of Parents and Children study. RESULTS: Mothers of children with CNVs reported higher frequency of depression, anorexia, bulimia, alcohol abuse and drug addiction problems compared with the age-matched mothers from the community sample. Focusing on psychiatric problems arising immediately after the birth of the index child, we found that the levels of depression symptoms were similar between the two groups (48% in mothers of children with CNVs vs 44% in mothers of the community sample, p=0.43), but mothers of children with CNVs had higher frequency of anxiety symptoms (55%) compared with mothers from the community sample (30%, p=0.03). CONCLUSION: Our study highlights the need for healthcare providers to devise treatment plans that not only focus on meeting the child’s needs but also assess and, if needed, address the mental health needs of the parent. BMJ Publishing Group 2023-07 2022-11-29 /pmc/articles/PMC10359584/ /pubmed/36446581 http://dx.doi.org/10.1136/jmg-2022-108752 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Copy-Number Variation Niarchou, Maria Cunningham, Adam C. Chawner, Samuel J. R. A. Moulding, Hayley Sopp, Matthew Hall, Jeremy Owen, Michael J. van den Bree, Marianne B.M. Psychopathology in mothers of children with pathogenic Copy Number Variants |
title | Psychopathology in mothers of children with pathogenic Copy Number Variants |
title_full | Psychopathology in mothers of children with pathogenic Copy Number Variants |
title_fullStr | Psychopathology in mothers of children with pathogenic Copy Number Variants |
title_full_unstemmed | Psychopathology in mothers of children with pathogenic Copy Number Variants |
title_short | Psychopathology in mothers of children with pathogenic Copy Number Variants |
title_sort | psychopathology in mothers of children with pathogenic copy number variants |
topic | Copy-Number Variation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359584/ https://www.ncbi.nlm.nih.gov/pubmed/36446581 http://dx.doi.org/10.1136/jmg-2022-108752 |
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