ATM phosphorylates the FATC domain of DNA-PK(cs) at threonine 4102 to promote non-homologous end joining

Ataxia-telangiectasia mutated (ATM) drives the DNA damage response via modulation of multiple signal transduction and DNA repair pathways. Previously, ATM activity was implicated in promoting the non-homologous end joining (NHEJ) pathway to repair a subset of DNA double-stranded breaks (DSBs), but h...

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Detalles Bibliográficos
Autores principales: Lu, Huiming, Zhang, Qin, Laverty, Daniel J, Puncheon, Andrew C, Augustine, Mathew M, Williams, Gareth J, Nagel, Zachary D, Chen, Benjamin P C, Davis, Anthony J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359628/
https://www.ncbi.nlm.nih.gov/pubmed/37309889
http://dx.doi.org/10.1093/nar/gkad505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359628/
https://www.ncbi.nlm.nih.gov/pubmed/37309889
http://dx.doi.org/10.1093/nar/gkad505

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