Cargando…

ATM phosphorylates the FATC domain of DNA-PK(cs) at threonine 4102 to promote non-homologous end joining

Ataxia-telangiectasia mutated (ATM) drives the DNA damage response via modulation of multiple signal transduction and DNA repair pathways. Previously, ATM activity was implicated in promoting the non-homologous end joining (NHEJ) pathway to repair a subset of DNA double-stranded breaks (DSBs), but h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Huiming, Zhang, Qin, Laverty, Daniel J, Puncheon, Andrew C, Augustine, Mathew M, Williams, Gareth J, Nagel, Zachary D, Chen, Benjamin P C, Davis, Anthony J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359628/ https://www.ncbi.nlm.nih.gov/pubmed/37309889 http://dx.doi.org/10.1093/nar/gkad505

Ejemplares similares

DNA-PK(cs)-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks
por: Lu, Huiming, et al.
Publicado: (2022)

DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining
por: Head, PamelaSara E, et al.
Publicado: (2023)

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
por: Liu, Shengqin, et al.
Publicado: (2012)

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK
por: Meyer, Barbara, et al.
Publicado: (2013)

Lif1 SUMOylation and its role in non-homologous end-joining
por: Vigasova, Dana, et al.
Publicado: (2013)

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation
por: Bakr, A., et al.
Publicado: (2015)

End-processing during non-homologous end-joining: a role for exonuclease 1
por: Bahmed, Karim, et al.
Publicado: (2011)

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways
por: Beck, Carole, et al.
Publicado: (2014)

A role for human homologous recombination factors in suppressing microhomology-mediated end joining
por: Ahrabi, Sara, et al.
Publicado: (2016)

Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase
por: Köcher, Sabrina, et al.
Publicado: (2012)

Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells
por: Renouf, Benjamin, et al.
Publicado: (2012)

MRE11 UFMylation promotes ATM activation
por: Wang, Zhifeng, et al.
Publicado: (2019)

Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting
por: Iiizumi, Susumu, et al.
Publicado: (2008)

Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity
por: Kirkman, Laura A., et al.
Publicado: (2014)

Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis
por: Öz, Robin, et al.
Publicado: (2021)

A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks
por: Hatkevich, Talia, et al.
Publicado: (2021)

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining
por: Kawale, Ajinkya S, et al.
Publicado: (2018)

DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1
por: Calkins, Anne S., et al.
Publicado: (2013)

DNA polymerase beta participates in DNA End-joining
por: Ray, Sreerupa, et al.
Publicado: (2018)

Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining
por: Zong, Dali, et al.
Publicado: (2015)

Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joining
por: Liang, Zhuobin, et al.
Publicado: (2016)

USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing
por: Kim, Jae Jin, et al.
Publicado: (2021)

Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku–DNA interaction
por: Gavande, Navnath S, et al.
Publicado: (2020)

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
por: Jungmichel, Stephanie, et al.
Publicado: (2012)

H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions
por: Feng, Yi-Li, et al.
Publicado: (2017)

The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF
por: Jessulat, Matthew, et al.
Publicado: (2021)

The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair
por: Fenton, Amanda L., et al.
Publicado: (2013)

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1
por: Kijas, Amanda W., et al.
Publicado: (2015)

ATM and KAT5 safeguard replicating chromatin against formaldehyde damage
por: Ortega-Atienza, Sara, et al.
Publicado: (2016)

Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair
por: Kumar, Varun, et al.
Publicado: (2017)

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1
por: Quennet, Verena, et al.
Publicado: (2011)

Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation
por: Shen, Mengyu, et al.
Publicado: (2018)

Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity
por: Olmedo-Pelayo, Joaquín, et al.
Publicado: (2020)

XRCC4's interaction with XLF is required for coding (but not signal) end joining
por: Roy, Sunetra, et al.
Publicado: (2012)

Control of alternative end joining by the chromatin remodeler p400 ATPase
por: Taty-Taty, Gemael-Cedrick, et al.
Publicado: (2016)

Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system
por: Zhao, Bailin, et al.
Publicado: (2020)

USP14 is a deubiquitinase for Ku70 and critical determinant of non-homologous end joining repair in autophagy and PTEN-deficient cells
por: Sharma, Arishya, et al.
Publicado: (2020)

Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair
por: Yang, Linlin, et al.
Publicado: (2021)

Sp1 phosphorylation by ATM downregulates BER and promotes cell elimination in response to persistent DNA damage
por: Fletcher, Sally C, et al.
Publicado: (2018)

ATM induces MacroD2 nuclear export upon DNA damage
por: Golia, Barbara, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ei9l3n6lkn5f9di9ienmmstdp6