Cargando…

Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease

Dysregulated bile acid (BA)/lipid metabolism and gut bacteria dysbiosis are tightly associated with the development of obesity and non-alcoholic fatty liver disease (NAFLD). The orphan nuclear receptor, Small Heterodimer Partner (SHP/NR0B2), is a key regulator of BA/lipid metabolism, and its gene-re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Young-Chae, Qi, Ming, Dong, Xingchen, Seok, Sunmi, Sun, Hao, Kemper, Byron, Fu, Ting, Kemper, Jongsook Kim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359637/ https://www.ncbi.nlm.nih.gov/pubmed/37348559 http://dx.doi.org/10.1016/j.jbc.2023.104946

Ejemplares similares

Feeding activates FGF15‐SHP‐TFEB‐mediated lipophagy in the gut
por: Seok, Sunmi, et al.
Publicado: (2022)

Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2
por: Kim, Young-Chae, et al.
Publicado: (2015)

Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
por: Kim, Young-Chae, et al.
Publicado: (2020)

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
por: Byun, Sangwon, et al.
Publicado: (2018)

Obesity-induced miR-802 directly targets AMPK and promotes nonalcoholic steatohepatitis in mice
por: Sun, Hao, et al.
Publicado: (2022)

AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle
por: Kim, Young-Chae, et al.
Publicado: (2018)

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
por: Byun, Sangwon, et al.
Publicado: (2020)

Cross-Regulation of Protein Stability by p53 and Nuclear Receptor SHP
por: Yang, Zhihong, et al.
Publicado: (2012)

MicroRNA regulation of AMPK in nonalcoholic fatty liver disease
por: Sun, Hao, et al.
Publicado: (2023)

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis
por: Kim, Dong-Hyun, et al.
Publicado: (2016)

Controlling SIRT1 expression by microRNAs in health and metabolic disease
por: Lee, Jiyoung, et al.
Publicado: (2010)

Transcriptional regulation of autophagy by an FXR/CREB axis
por: Seok, Sunmi, et al.
Publicado: (2014)

The Black Box Orchestra of Gut Bacteria and Bile Acids: Who Is the Conductor?
por: Majait, Soumia, et al.
Publicado: (2023)

BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination
por: Jung, Hyunkyung, et al.
Publicado: (2020)

Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages
por: Hu, Xiangming, et al.
Publicado: (2021)

Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors
por: Franciosa, Giulia, et al.
Publicado: (2023)

Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML
por: Pfeiffer, Anamarija, et al.
Publicado: (2022)

Grb2 binding induces phosphorylation-independent activation of Shp2
por: Lin, Chi-Chuan, et al.
Publicado: (2021)

Bacteria in milk from anterior and posterior mammary glands in sows affected and unaffected by postpartum dysgalactia syndrome (PPDS)
por: Kemper, Nicole, et al.
Publicado: (2009)

Global profiling of phosphorylation-dependent changes in cysteine reactivity
por: Kemper, Esther K., et al.
Publicado: (2022)

Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype
por: Christophi, George P., et al.
Publicado: (2009)

Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment
por: Stefanski, Adrianne L., et al.
Publicado: (2022)

Bile Salt and FGF19 Signaling in the Early Phase of Human Liver Regeneration
por: Koelfat, Kiran V.K., et al.
Publicado: (2021)

Examination of the hygienic status of selected organic enrichment materials used in pig farming with special emphasis on pathogenic bacteria
por: Wagner, Krista Marie, et al.
Publicado: (2018)

The Role of FGF19 and MALRD1 in Enterohepatic Bile Acid Signaling
por: Wang, Linda X., et al.
Publicado: (2022)

PMON295 Investigating the ileal FXR/SHP axis in regulating lipid absorption and enterohepatic recirculation of bile acids
por: Nguyen, James, et al.
Publicado: (2022)

Generation of FGF reporter transgenic zebrafish and their utility in chemical screens
por: Molina, Gabriela A, et al.
Publicado: (2007)

Transgenic Expression of Nonclassically Secreted FGF Suppresses Kidney Repair
por: Kirov, Aleksandr, et al.
Publicado: (2012)

Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease
por: Kim, Sun-Gi, et al.
Publicado: (2016)

LKB1 in Intestinal Epithelial Cells Regulates Bile Acid Metabolism by Modulating FGF15/19 Production
por: Kim, Yeji, et al.
Publicado: (2021)

Destabilization of the SHP2 and SHP1 protein tyrosine phosphatase domains by a non-conserved “backdoor” cysteine
por: Yarnall, Matthew T.N., et al.
Publicado: (2022)

Selective inhibition of leukemia-associated SHP2(E69K) mutant by the allosteric SHP2 inhibitor SHP099
por: Sun, X, et al.
Publicado: (2018)

Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function
por: Zhang, Yuxia, et al.
Publicado: (2016)

Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis
por: Katafuchi, Takeshi, et al.
Publicado: (2022)

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
por: Ahmed, Zamal, et al.
Publicado: (2013)

Protein kinase D regulates positive selection of CD4(+) thymocytes through phosphorylation of SHP-1
por: Ishikawa, Eri, et al.
Publicado: (2016)

A LILRB1 variant with a decreased ability to phosphorylate SHP-1 leads to autoimmune diseases
por: Sinthuwiwat, Thivaratana, et al.
Publicado: (2022)

Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1/AMPK Signaling Pathway
por: Yu, Peng, et al.
Publicado: (2019)

Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma
por: Schneeberger, Valentina E., et al.
Publicado: (2015)

Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease
por: Wang, Caihua, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_b6qsod1d4iu49vivpik6cm7b6s