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Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease

Dysregulated bile acid (BA)/lipid metabolism and gut bacteria dysbiosis are tightly associated with the development of obesity and non-alcoholic fatty liver disease (NAFLD). The orphan nuclear receptor, Small Heterodimer Partner (SHP/NR0B2), is a key regulator of BA/lipid metabolism, and its gene-re...

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Detalles Bibliográficos
Autores principales:	Kim, Young-Chae, Qi, Ming, Dong, Xingchen, Seok, Sunmi, Sun, Hao, Kemper, Byron, Fu, Ting, Kemper, Jongsook Kim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359637/ https://www.ncbi.nlm.nih.gov/pubmed/37348559 http://dx.doi.org/10.1016/j.jbc.2023.104946

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