Bilateral Cystoid Macular Edema with Zanubrutinib Therapy: A Case Report

We present a patient with recurrent mantle cell lymphoma (MCL) who was treated with zanubrutinib, a Bruton’s tyrosine kinase inhibitor. He subsequently developed bilateral cystoid macular edema (CME) in both eyes. This is the first report of CME in a patient with MCL who was treated with zanubrutini...

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Autores principales: Pennipede, Dante, Sciulli, Harrison, Ajlan, Radwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359683/
https://www.ncbi.nlm.nih.gov/pubmed/37485014
http://dx.doi.org/10.1159/000529069
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author Pennipede, Dante
Sciulli, Harrison
Ajlan, Radwan
author_facet Pennipede, Dante
Sciulli, Harrison
Ajlan, Radwan
author_sort Pennipede, Dante
collection PubMed
description We present a patient with recurrent mantle cell lymphoma (MCL) who was treated with zanubrutinib, a Bruton’s tyrosine kinase inhibitor. He subsequently developed bilateral cystoid macular edema (CME) in both eyes. This is the first report of CME in a patient with MCL who was treated with zanubrutinib. CME was refractory to topical corticosteroid therapy, but sub-Tenon’s steroid injections and holding off zanubrutinib managed to decrease the CME. Treatment managed to prevent further vision loss but did not restore lost vision. The prompt ophthalmic exam is recommended for patients on zanubrutinib with decreased vision.
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spelling pubmed-103596832023-07-22 Bilateral Cystoid Macular Edema with Zanubrutinib Therapy: A Case Report Pennipede, Dante Sciulli, Harrison Ajlan, Radwan Case Rep Oncol Case Report We present a patient with recurrent mantle cell lymphoma (MCL) who was treated with zanubrutinib, a Bruton’s tyrosine kinase inhibitor. He subsequently developed bilateral cystoid macular edema (CME) in both eyes. This is the first report of CME in a patient with MCL who was treated with zanubrutinib. CME was refractory to topical corticosteroid therapy, but sub-Tenon’s steroid injections and holding off zanubrutinib managed to decrease the CME. Treatment managed to prevent further vision loss but did not restore lost vision. The prompt ophthalmic exam is recommended for patients on zanubrutinib with decreased vision. S. Karger AG 2023-07-13 /pmc/articles/PMC10359683/ /pubmed/37485014 http://dx.doi.org/10.1159/000529069 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Pennipede, Dante
Sciulli, Harrison
Ajlan, Radwan
Bilateral Cystoid Macular Edema with Zanubrutinib Therapy: A Case Report
title Bilateral Cystoid Macular Edema with Zanubrutinib Therapy: A Case Report
title_full Bilateral Cystoid Macular Edema with Zanubrutinib Therapy: A Case Report
title_fullStr Bilateral Cystoid Macular Edema with Zanubrutinib Therapy: A Case Report
title_full_unstemmed Bilateral Cystoid Macular Edema with Zanubrutinib Therapy: A Case Report
title_short Bilateral Cystoid Macular Edema with Zanubrutinib Therapy: A Case Report
title_sort bilateral cystoid macular edema with zanubrutinib therapy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359683/
https://www.ncbi.nlm.nih.gov/pubmed/37485014
http://dx.doi.org/10.1159/000529069
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