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Associations of systemic inflammation markers with myocardial enzymes in pediatric adenotonsillar hypertrophy: A cross-sectional study

OBJECTIVE: The present study aimed to investigate the relationship between systemic inflammation markers and myocardial enzymes in children with adenotonsillar hypertrophy (ATH). METHODS: The levels of myocardial enzymes were detected and the systemic inflammatory biomarkers including neutrophil-lym...

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Autores principales: Han, Yingying, Guo, Ruixiang, Feng, Ziyu, Wang, Haipeng, Li, Yanzhong, Zou, Juanjuan, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359822/
https://www.ncbi.nlm.nih.gov/pubmed/37483768
http://dx.doi.org/10.1016/j.heliyon.2023.e17719
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author Han, Yingying
Guo, Ruixiang
Feng, Ziyu
Wang, Haipeng
Li, Yanzhong
Zou, Juanjuan
Wang, Yan
author_facet Han, Yingying
Guo, Ruixiang
Feng, Ziyu
Wang, Haipeng
Li, Yanzhong
Zou, Juanjuan
Wang, Yan
author_sort Han, Yingying
collection PubMed
description OBJECTIVE: The present study aimed to investigate the relationship between systemic inflammation markers and myocardial enzymes in children with adenotonsillar hypertrophy (ATH). METHODS: The levels of myocardial enzymes were detected and the systemic inflammatory biomarkers including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and systemic immune inflammation index (SII) were calculated. Regression analyses were performed and a prediction model for screening myocardial injury was established by receiver operating characteristic (ROC) curve. RESULTS: Finally, a total of 804 children with ATH were included. After adjusting for age, BMI, fasting blood glucose and lipid profiles, both NLR and SII were significantly associated with CK-MB (p = 0.041 and 0.034, respectively) and LDH (p = 0.002 and 0.001, respectively), and PLR was associated with CK-MB (p = 0.008). In addition, NLR, SII were independently associated with hyper-LDH [OR = 1.447, 95%CI (1.063, 1.968); OR = 1.001, 95%CI (1.000, 1.002), respectively] and the associations were more significant in girls. A prediction model for hyper-LDH based on SII was developed with the area under the ROC curve of 0.715 (0.682, 0.746). CONCLUSION: Systemic inflammation markers were only independently associated with serum hyper-LDH in children with ATH, especially in girls. Further investigation was needed to determine the relationship between systemic inflammation with myocardial enzymes in ATH children.
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spelling pubmed-103598222023-07-22 Associations of systemic inflammation markers with myocardial enzymes in pediatric adenotonsillar hypertrophy: A cross-sectional study Han, Yingying Guo, Ruixiang Feng, Ziyu Wang, Haipeng Li, Yanzhong Zou, Juanjuan Wang, Yan Heliyon Research Article OBJECTIVE: The present study aimed to investigate the relationship between systemic inflammation markers and myocardial enzymes in children with adenotonsillar hypertrophy (ATH). METHODS: The levels of myocardial enzymes were detected and the systemic inflammatory biomarkers including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and systemic immune inflammation index (SII) were calculated. Regression analyses were performed and a prediction model for screening myocardial injury was established by receiver operating characteristic (ROC) curve. RESULTS: Finally, a total of 804 children with ATH were included. After adjusting for age, BMI, fasting blood glucose and lipid profiles, both NLR and SII were significantly associated with CK-MB (p = 0.041 and 0.034, respectively) and LDH (p = 0.002 and 0.001, respectively), and PLR was associated with CK-MB (p = 0.008). In addition, NLR, SII were independently associated with hyper-LDH [OR = 1.447, 95%CI (1.063, 1.968); OR = 1.001, 95%CI (1.000, 1.002), respectively] and the associations were more significant in girls. A prediction model for hyper-LDH based on SII was developed with the area under the ROC curve of 0.715 (0.682, 0.746). CONCLUSION: Systemic inflammation markers were only independently associated with serum hyper-LDH in children with ATH, especially in girls. Further investigation was needed to determine the relationship between systemic inflammation with myocardial enzymes in ATH children. Elsevier 2023-07-01 /pmc/articles/PMC10359822/ /pubmed/37483768 http://dx.doi.org/10.1016/j.heliyon.2023.e17719 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Han, Yingying
Guo, Ruixiang
Feng, Ziyu
Wang, Haipeng
Li, Yanzhong
Zou, Juanjuan
Wang, Yan
Associations of systemic inflammation markers with myocardial enzymes in pediatric adenotonsillar hypertrophy: A cross-sectional study
title Associations of systemic inflammation markers with myocardial enzymes in pediatric adenotonsillar hypertrophy: A cross-sectional study
title_full Associations of systemic inflammation markers with myocardial enzymes in pediatric adenotonsillar hypertrophy: A cross-sectional study
title_fullStr Associations of systemic inflammation markers with myocardial enzymes in pediatric adenotonsillar hypertrophy: A cross-sectional study
title_full_unstemmed Associations of systemic inflammation markers with myocardial enzymes in pediatric adenotonsillar hypertrophy: A cross-sectional study
title_short Associations of systemic inflammation markers with myocardial enzymes in pediatric adenotonsillar hypertrophy: A cross-sectional study
title_sort associations of systemic inflammation markers with myocardial enzymes in pediatric adenotonsillar hypertrophy: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359822/
https://www.ncbi.nlm.nih.gov/pubmed/37483768
http://dx.doi.org/10.1016/j.heliyon.2023.e17719
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