Cargando…

Assessment of the association of CYP1A1 gene polymorphisms with the susceptibility of cervical cancer: A case-control study and meta-analysis

BACKGROUND: Cervical cancer (CC) is the second most common type of female malignancy in Bangladesh. Polymorphisms in the CYP1A1 gene have been reported to be associated with CC in different populations. This case-control study with meta-analysis was undertaken to assess the relation of CYP1A1 rs4646...

Descripción completa

Detalles Bibliográficos
Autores principales: Barek, Md. Abdul, Basher, Mohammad Anwarul, Aziz, Md. Abdul, Hossen, Md. Shafiul, Jahan, Nusrat, Afroz, Nahida, Begum, Mobashera, Jafrin, Sarah, Uddin, Mohammad Sarowar, Millat, Md. Shalahuddin, Hoque, Md. Mahmudul, Islam, Mohammad Safiqul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359826/
https://www.ncbi.nlm.nih.gov/pubmed/37483787
http://dx.doi.org/10.1016/j.heliyon.2023.e17712
_version_ 1785075969186332672
author Barek, Md. Abdul
Basher, Mohammad Anwarul
Aziz, Md. Abdul
Hossen, Md. Shafiul
Jahan, Nusrat
Afroz, Nahida
Begum, Mobashera
Jafrin, Sarah
Uddin, Mohammad Sarowar
Millat, Md. Shalahuddin
Hoque, Md. Mahmudul
Islam, Mohammad Safiqul
author_facet Barek, Md. Abdul
Basher, Mohammad Anwarul
Aziz, Md. Abdul
Hossen, Md. Shafiul
Jahan, Nusrat
Afroz, Nahida
Begum, Mobashera
Jafrin, Sarah
Uddin, Mohammad Sarowar
Millat, Md. Shalahuddin
Hoque, Md. Mahmudul
Islam, Mohammad Safiqul
author_sort Barek, Md. Abdul
collection PubMed
description BACKGROUND: Cervical cancer (CC) is the second most common type of female malignancy in Bangladesh. Polymorphisms in the CYP1A1 gene have been reported to be associated with CC in different populations. This case-control study with meta-analysis was undertaken to assess the relation of CYP1A1 rs4646903 and rs1048943 polymorphisms with the susceptibility of CC. METHODS: A total of 185 CC patients and 220 controls were recruited, and the PCR-RFLP (Polymerase chain reaction-restriction fragment length polymorphism) technique was applied for genotyping. Again, 42 eligible studies (24 with rs4646903 and 18 with rs1048943) were included for meta-analysis, and RevMan 5.3 and the MetaGenyo web-based tool were used. RESULTS: The rs4646903 polymorphism was significantly linked with CC in all association models, namely, additive 1, additive 2, dominant, recessive, overdominant, and allele models (OR = 2.41, 4.75, 2.67, 3.61, 2.13, and 2.44 with corresponding 95% CI = 1.55–3.76, 1.81–12.45, 1.75–4.07, 1.39–9.35, 1.38–3.30, and 1.71–3.48, respectively). On the contrary, rs1048943 showed no association (p > 0.05) with CC. Haplotype analysis revealed AT and AC haplotypes significantly decreased (OR = 0.45) and increased (OR = 4.86) CC risk, respectively, and SNPs are in strong linkage disequilibrium (D’ = 0.912, r(2) = 0.448). Again, rs4646903 carriers with a contraception history and >5 years of taking contraceptives showed an enhanced risk of CC (OR = 2.39, OR = 3.05). Besides, rs1048943 carriers aged >40 years (OR = 0.44), conceived first child aged ≤18 years (OR = 3.45), and history of contraceptives (OR = 2.18) were significantly linked with CC. Our meta-analysis found that for CYP1A1 rs4646903 codominant 1 (COD 1), codominant 2 (COD 2), codominant 3 (COD 3), dominant model (DM), recessive model (RM), and allele model (AM) in Caucasians and overdominant model (OD) in the overall population are associated with an elevated risk of CC, whereas rs1048943 is also associated with CC in overall, Caucasians and Asians in some genetic models. CONCLUSION: Our case-control study and meta-analysis summarize that CYP1A1 rs4646903 and rs1048943 polymorphisms may be correlated with cervical cancer.
format Online
Article
Text
id pubmed-10359826
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-103598262023-07-22 Assessment of the association of CYP1A1 gene polymorphisms with the susceptibility of cervical cancer: A case-control study and meta-analysis Barek, Md. Abdul Basher, Mohammad Anwarul Aziz, Md. Abdul Hossen, Md. Shafiul Jahan, Nusrat Afroz, Nahida Begum, Mobashera Jafrin, Sarah Uddin, Mohammad Sarowar Millat, Md. Shalahuddin Hoque, Md. Mahmudul Islam, Mohammad Safiqul Heliyon Research Article BACKGROUND: Cervical cancer (CC) is the second most common type of female malignancy in Bangladesh. Polymorphisms in the CYP1A1 gene have been reported to be associated with CC in different populations. This case-control study with meta-analysis was undertaken to assess the relation of CYP1A1 rs4646903 and rs1048943 polymorphisms with the susceptibility of CC. METHODS: A total of 185 CC patients and 220 controls were recruited, and the PCR-RFLP (Polymerase chain reaction-restriction fragment length polymorphism) technique was applied for genotyping. Again, 42 eligible studies (24 with rs4646903 and 18 with rs1048943) were included for meta-analysis, and RevMan 5.3 and the MetaGenyo web-based tool were used. RESULTS: The rs4646903 polymorphism was significantly linked with CC in all association models, namely, additive 1, additive 2, dominant, recessive, overdominant, and allele models (OR = 2.41, 4.75, 2.67, 3.61, 2.13, and 2.44 with corresponding 95% CI = 1.55–3.76, 1.81–12.45, 1.75–4.07, 1.39–9.35, 1.38–3.30, and 1.71–3.48, respectively). On the contrary, rs1048943 showed no association (p > 0.05) with CC. Haplotype analysis revealed AT and AC haplotypes significantly decreased (OR = 0.45) and increased (OR = 4.86) CC risk, respectively, and SNPs are in strong linkage disequilibrium (D’ = 0.912, r(2) = 0.448). Again, rs4646903 carriers with a contraception history and >5 years of taking contraceptives showed an enhanced risk of CC (OR = 2.39, OR = 3.05). Besides, rs1048943 carriers aged >40 years (OR = 0.44), conceived first child aged ≤18 years (OR = 3.45), and history of contraceptives (OR = 2.18) were significantly linked with CC. Our meta-analysis found that for CYP1A1 rs4646903 codominant 1 (COD 1), codominant 2 (COD 2), codominant 3 (COD 3), dominant model (DM), recessive model (RM), and allele model (AM) in Caucasians and overdominant model (OD) in the overall population are associated with an elevated risk of CC, whereas rs1048943 is also associated with CC in overall, Caucasians and Asians in some genetic models. CONCLUSION: Our case-control study and meta-analysis summarize that CYP1A1 rs4646903 and rs1048943 polymorphisms may be correlated with cervical cancer. Elsevier 2023-07-04 /pmc/articles/PMC10359826/ /pubmed/37483787 http://dx.doi.org/10.1016/j.heliyon.2023.e17712 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Barek, Md. Abdul
Basher, Mohammad Anwarul
Aziz, Md. Abdul
Hossen, Md. Shafiul
Jahan, Nusrat
Afroz, Nahida
Begum, Mobashera
Jafrin, Sarah
Uddin, Mohammad Sarowar
Millat, Md. Shalahuddin
Hoque, Md. Mahmudul
Islam, Mohammad Safiqul
Assessment of the association of CYP1A1 gene polymorphisms with the susceptibility of cervical cancer: A case-control study and meta-analysis
title Assessment of the association of CYP1A1 gene polymorphisms with the susceptibility of cervical cancer: A case-control study and meta-analysis
title_full Assessment of the association of CYP1A1 gene polymorphisms with the susceptibility of cervical cancer: A case-control study and meta-analysis
title_fullStr Assessment of the association of CYP1A1 gene polymorphisms with the susceptibility of cervical cancer: A case-control study and meta-analysis
title_full_unstemmed Assessment of the association of CYP1A1 gene polymorphisms with the susceptibility of cervical cancer: A case-control study and meta-analysis
title_short Assessment of the association of CYP1A1 gene polymorphisms with the susceptibility of cervical cancer: A case-control study and meta-analysis
title_sort assessment of the association of cyp1a1 gene polymorphisms with the susceptibility of cervical cancer: a case-control study and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359826/
https://www.ncbi.nlm.nih.gov/pubmed/37483787
http://dx.doi.org/10.1016/j.heliyon.2023.e17712
work_keys_str_mv AT barekmdabdul assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis
AT bashermohammadanwarul assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis
AT azizmdabdul assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis
AT hossenmdshafiul assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis
AT jahannusrat assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis
AT afroznahida assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis
AT begummobashera assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis
AT jafrinsarah assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis
AT uddinmohammadsarowar assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis
AT millatmdshalahuddin assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis
AT hoquemdmahmudul assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis
AT islammohammadsafiqul assessmentoftheassociationofcyp1a1genepolymorphismswiththesusceptibilityofcervicalcanceracasecontrolstudyandmetaanalysis