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Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial
INTRODUCTION: The aim of this study was to evaluate the effectiveness of a real-life clinical physical activity program (DIAfit) on improving physical fitness, body composition, and cardiometabolic health in an unselected population with type 2 diabetes mellitus, and to compare the effects of two va...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359883/ https://www.ncbi.nlm.nih.gov/pubmed/37484961 http://dx.doi.org/10.3389/fendo.2023.1155217 |
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author | Arhab, Amar Junod, Nicolas Rossel, Jean-Benoit Giet, Olivier Sittarame, Frederic Beer, Sandra Sofra, Daniela Durrer, Dominique Delgado, Humberto Castellsague, Montserrat Laimer, Markus Puder, Jardena J. |
author_facet | Arhab, Amar Junod, Nicolas Rossel, Jean-Benoit Giet, Olivier Sittarame, Frederic Beer, Sandra Sofra, Daniela Durrer, Dominique Delgado, Humberto Castellsague, Montserrat Laimer, Markus Puder, Jardena J. |
author_sort | Arhab, Amar |
collection | PubMed |
description | INTRODUCTION: The aim of this study was to evaluate the effectiveness of a real-life clinical physical activity program (DIAfit) on improving physical fitness, body composition, and cardiometabolic health in an unselected population with type 2 diabetes mellitus, and to compare the effects of two variants a different exercise frequencies on the same outcomes. RESEARCH DESIGN AND METHODS: This was a cluster randomized-controlled assessor-blind trial conducted in 11 clinical centres in Switzerland. All participants in the clinical program with type 2 diabetes were eligible and were randomized to either standard (3 sessions/week for 12 weeks) or alternative (1 session/week for the first four weeks, then 2 sessions/week for the rest of 16 weeks) physical activity program each consisting of 36 sessions of combined aerobic and resistance exercise. Allocation was concealed by a central office unrelated to the study. The primary outcome was aerobic fitness. Secondary outcome measures included: body composition, BMI, HbA(1c), muscle strength, walking speed, balance, flexibility, blood pressure, lipid profile. RESULTS: All 185 patients with type 2 diabetes (mean age 59.7 +-10.2 years, 48% women) agreed to participate and were randomized in two groups: a standard group (n=88) and an alternative group (n=97)). There was an 11% increase in aerobic fitness after the program (12.5 Watts; 95% CI 6.76 to 18.25; p<0.001). Significant improvements in physical fitness, body composition, and cardiometabolic parameters were observed at the end of the DIAfit program (improvements between 2-29%) except for lean body mass, triglycerides and cholesterol. No differences were observed between both programs, except for a larger weight reduction of -0.97kg (95% CI -0.04 to -1.91; p=0.04) in the standard program. CONCLUSIONS: Both frequency variants of the nation-wide DIAfit program had beneficial effects on physical fitness, HbA(1c), body composition, and blood pressure in type 2 diabetes patients and differences were negligible. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov, identifier NCT01289587. |
format | Online Article Text |
id | pubmed-10359883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103598832023-07-22 Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial Arhab, Amar Junod, Nicolas Rossel, Jean-Benoit Giet, Olivier Sittarame, Frederic Beer, Sandra Sofra, Daniela Durrer, Dominique Delgado, Humberto Castellsague, Montserrat Laimer, Markus Puder, Jardena J. Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: The aim of this study was to evaluate the effectiveness of a real-life clinical physical activity program (DIAfit) on improving physical fitness, body composition, and cardiometabolic health in an unselected population with type 2 diabetes mellitus, and to compare the effects of two variants a different exercise frequencies on the same outcomes. RESEARCH DESIGN AND METHODS: This was a cluster randomized-controlled assessor-blind trial conducted in 11 clinical centres in Switzerland. All participants in the clinical program with type 2 diabetes were eligible and were randomized to either standard (3 sessions/week for 12 weeks) or alternative (1 session/week for the first four weeks, then 2 sessions/week for the rest of 16 weeks) physical activity program each consisting of 36 sessions of combined aerobic and resistance exercise. Allocation was concealed by a central office unrelated to the study. The primary outcome was aerobic fitness. Secondary outcome measures included: body composition, BMI, HbA(1c), muscle strength, walking speed, balance, flexibility, blood pressure, lipid profile. RESULTS: All 185 patients with type 2 diabetes (mean age 59.7 +-10.2 years, 48% women) agreed to participate and were randomized in two groups: a standard group (n=88) and an alternative group (n=97)). There was an 11% increase in aerobic fitness after the program (12.5 Watts; 95% CI 6.76 to 18.25; p<0.001). Significant improvements in physical fitness, body composition, and cardiometabolic parameters were observed at the end of the DIAfit program (improvements between 2-29%) except for lean body mass, triglycerides and cholesterol. No differences were observed between both programs, except for a larger weight reduction of -0.97kg (95% CI -0.04 to -1.91; p=0.04) in the standard program. CONCLUSIONS: Both frequency variants of the nation-wide DIAfit program had beneficial effects on physical fitness, HbA(1c), body composition, and blood pressure in type 2 diabetes patients and differences were negligible. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov, identifier NCT01289587. Frontiers Media S.A. 2023-07-03 /pmc/articles/PMC10359883/ /pubmed/37484961 http://dx.doi.org/10.3389/fendo.2023.1155217 Text en Copyright © 2023 Arhab, Junod, Rossel, Giet, Sittarame, Beer, Sofra, Durrer, Delgado, Castellsague, Laimer and Puder https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Arhab, Amar Junod, Nicolas Rossel, Jean-Benoit Giet, Olivier Sittarame, Frederic Beer, Sandra Sofra, Daniela Durrer, Dominique Delgado, Humberto Castellsague, Montserrat Laimer, Markus Puder, Jardena J. Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
title | Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
title_full | Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
title_fullStr | Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
title_full_unstemmed | Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
title_short | Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
title_sort | effectiveness of a real-life program (diafit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359883/ https://www.ncbi.nlm.nih.gov/pubmed/37484961 http://dx.doi.org/10.3389/fendo.2023.1155217 |
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