Identification and characterisation of anti-IL-13 inhibitory single domain antibodies provides new insights into receptor selectivity and attractive opportunities for drug discovery

Interleukin-13 (IL-13) is a cytokine involved in T-cell immune responses and is a well validated therapeutic target for the treatment of asthma, along with other allergic and inflammatory diseases. IL-13 signals through a ternary signalling complex formed with the receptors IL-13Rα1 and IL-4Rα. This...

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Detalles Bibliográficos
Autores principales: Walker, Kayleigh, Baravalle, Roberta, Holyfield, Rachel, Kalms, Jacqueline, Wright, Helena, Seewooruthun, Chitra, Muskett, Frederick W., Scott-Tucker, Anthony, Merritt, Andy, Henry, Alistair, Lawson, Alastair D. G., Hall, Gareth, Prosser, Christine, Carr, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359924/
https://www.ncbi.nlm.nih.gov/pubmed/37483614
http://dx.doi.org/10.3389/fimmu.2023.1216967

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