Free ferrous ions sustain activity of mammalian stearoyl-CoA desaturase-1

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Mammalian stearoyl-CoA desaturase-1 (SCD1) introduces a double-bond to a saturated long-chain fatty acid in a reaction catalyzed by a diiron center. The diiron center is well-coordinated by conserved histidine residues and is thought to remain with the enzyme. However, we find here that SCD1 progres...

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Detalles Bibliográficos
Autores principales: Shen, Jiemin, Wu, Gang, Pierce, Brad S., Tsai, Ah-Lim, Zhou, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359943/
https://www.ncbi.nlm.nih.gov/pubmed/37290533
http://dx.doi.org/10.1016/j.jbc.2023.104897

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