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Targeted transcutaneous spinal cord stimulation promotes persistent recovery of upper limb strength and tactile sensation in spinal cord injury: a pilot study

Long-term recovery of limb function is a significant unmet need in people with paralysis. Neuromodulation of the spinal cord through epidural stimulation, when paired with intense activity-based training, has shown promising results toward restoring volitional limb control in people with spinal cord...

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Autores principales: Chandrasekaran, Santosh, Bhagat, Nikunj A., Ramdeo, Richard, Ebrahimi, Sadegh, Sharma, Pawan D., Griffin, Doug G., Stein, Adam, Harkema, Susan J., Bouton, Chad E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360050/
https://www.ncbi.nlm.nih.gov/pubmed/37483349
http://dx.doi.org/10.3389/fnins.2023.1210328
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author Chandrasekaran, Santosh
Bhagat, Nikunj A.
Ramdeo, Richard
Ebrahimi, Sadegh
Sharma, Pawan D.
Griffin, Doug G.
Stein, Adam
Harkema, Susan J.
Bouton, Chad E.
author_facet Chandrasekaran, Santosh
Bhagat, Nikunj A.
Ramdeo, Richard
Ebrahimi, Sadegh
Sharma, Pawan D.
Griffin, Doug G.
Stein, Adam
Harkema, Susan J.
Bouton, Chad E.
author_sort Chandrasekaran, Santosh
collection PubMed
description Long-term recovery of limb function is a significant unmet need in people with paralysis. Neuromodulation of the spinal cord through epidural stimulation, when paired with intense activity-based training, has shown promising results toward restoring volitional limb control in people with spinal cord injury. Non-invasive neuromodulation of the cervical spinal cord using transcutaneous spinal cord stimulation (tSCS) has shown similar improvements in upper-limb motor control rehabilitation. However, the motor and sensory rehabilitative effects of activating specific cervical spinal segments using tSCS have largely remained unexplored. We show in two individuals with motor-complete SCI that targeted stimulation of the cervical spinal cord resulted in up to a 1,136% increase in exerted force, with weekly activity-based training. Furthermore, this is the first study to document up to a 2-point improvement in clinical assessment of tactile sensation in SCI after receiving tSCS. Lastly, participant gains persisted after a one-month period void of stimulation, suggesting that targeted tSCS may lead to persistent recovery of motor and sensory function.
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spelling pubmed-103600502023-07-22 Targeted transcutaneous spinal cord stimulation promotes persistent recovery of upper limb strength and tactile sensation in spinal cord injury: a pilot study Chandrasekaran, Santosh Bhagat, Nikunj A. Ramdeo, Richard Ebrahimi, Sadegh Sharma, Pawan D. Griffin, Doug G. Stein, Adam Harkema, Susan J. Bouton, Chad E. Front Neurosci Neuroscience Long-term recovery of limb function is a significant unmet need in people with paralysis. Neuromodulation of the spinal cord through epidural stimulation, when paired with intense activity-based training, has shown promising results toward restoring volitional limb control in people with spinal cord injury. Non-invasive neuromodulation of the cervical spinal cord using transcutaneous spinal cord stimulation (tSCS) has shown similar improvements in upper-limb motor control rehabilitation. However, the motor and sensory rehabilitative effects of activating specific cervical spinal segments using tSCS have largely remained unexplored. We show in two individuals with motor-complete SCI that targeted stimulation of the cervical spinal cord resulted in up to a 1,136% increase in exerted force, with weekly activity-based training. Furthermore, this is the first study to document up to a 2-point improvement in clinical assessment of tactile sensation in SCI after receiving tSCS. Lastly, participant gains persisted after a one-month period void of stimulation, suggesting that targeted tSCS may lead to persistent recovery of motor and sensory function. Frontiers Media S.A. 2023-07-07 /pmc/articles/PMC10360050/ /pubmed/37483349 http://dx.doi.org/10.3389/fnins.2023.1210328 Text en Copyright © 2023 Chandrasekaran, Bhagat, Ramdeo, Ebrahimi, Sharma, Griffin, Stein, Harkema and Bouton. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Chandrasekaran, Santosh
Bhagat, Nikunj A.
Ramdeo, Richard
Ebrahimi, Sadegh
Sharma, Pawan D.
Griffin, Doug G.
Stein, Adam
Harkema, Susan J.
Bouton, Chad E.
Targeted transcutaneous spinal cord stimulation promotes persistent recovery of upper limb strength and tactile sensation in spinal cord injury: a pilot study
title Targeted transcutaneous spinal cord stimulation promotes persistent recovery of upper limb strength and tactile sensation in spinal cord injury: a pilot study
title_full Targeted transcutaneous spinal cord stimulation promotes persistent recovery of upper limb strength and tactile sensation in spinal cord injury: a pilot study
title_fullStr Targeted transcutaneous spinal cord stimulation promotes persistent recovery of upper limb strength and tactile sensation in spinal cord injury: a pilot study
title_full_unstemmed Targeted transcutaneous spinal cord stimulation promotes persistent recovery of upper limb strength and tactile sensation in spinal cord injury: a pilot study
title_short Targeted transcutaneous spinal cord stimulation promotes persistent recovery of upper limb strength and tactile sensation in spinal cord injury: a pilot study
title_sort targeted transcutaneous spinal cord stimulation promotes persistent recovery of upper limb strength and tactile sensation in spinal cord injury: a pilot study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360050/
https://www.ncbi.nlm.nih.gov/pubmed/37483349
http://dx.doi.org/10.3389/fnins.2023.1210328
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