Native Top-Down Mass Spectrometry Uncovers Two Distinct Binding Motifs of a Functional Neomycin-Sensing Riboswitch Aptamer

[Image: see text] Understanding how ligands bind to ribonucleic acids (RNA) is important for understanding RNA recognition in biological processes and drug development. Here, we have studied neomycin B binding to neomycin-sensing riboswitch aptamer constructs by native top-down mass spectrometry (MS...

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Detalles Bibliográficos
Autores principales: Heel, Sarah Viola, Bartosik, Karolina, Juen, Fabian, Kreutz, Christoph, Micura, Ronald, Breuker, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360057/
https://www.ncbi.nlm.nih.gov/pubmed/37420313
http://dx.doi.org/10.1021/jacs.3c02774

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