Cargando…

Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury

Ras homolog enriched in brain (Rheb) is a small GTPase that activates mammalian target of rapamycin complex 1 (mTORC1). Previous studies have shown that constitutively active Rheb can enhance the regeneration of sensory axons after spinal cord injury by activating downstream effectors of mTOR. S6K1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Jikuan, Zhang, Lusi, Zou, Jingling, Liu, Jingyuan, Yang, Jia, Jiang, Qian, Duan, Peiyun, Jiang, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360084/ https://www.ncbi.nlm.nih.gov/pubmed/37282486 http://dx.doi.org/10.4103/1673-5374.371372

Ejemplares similares

Expressing Constitutively Active Rheb in Adult Dorsal Root Ganglion Neurons Enhances the Integration of Sensory Axons that Regenerate Across a Chondroitinase-Treated Dorsal Root Entry Zone Following Dorsal Root Crush
por: Wu, Di, et al.
Publicado: (2016)

Gene therapy and the regeneration of retinal ganglion cell axons
por: Harvey, Alan R.
Publicado: (2014)

Caspases in retinal ganglion cell death and axon regeneration
por: Thomas, Chloe N, et al.
Publicado: (2017)

Elk-1 regulates retinal ganglion cell axon regeneration after injury
por: Noro, Takahiko, et al.
Publicado: (2022)

The mTORC1 Effectors S6K1 and 4E-BP Play Different Roles in CNS Axon Regeneration
por: Yang, Liu, et al.
Publicado: (2014)

Retinal Glia Promote Dorsal Root Ganglion Axon Regeneration
por: Lorber, Barbara, et al.
Publicado: (2015)

Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells
Publicado: (1981)

Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush
por: Sharma, T P, et al.
Publicado: (2015)

Tsc2-Rheb Signaling Regulates EphA-Mediated Axon Guidance
por: Nie, Du-yu, et al.
Publicado: (2010)

Mesenchymal stem cell therapy for retinal ganglion cell neuroprotection and axon regeneration
por: Mead, Ben, et al.
Publicado: (2015)

Different Effect of Sox11 in Retinal Ganglion Cells Survival and Axon Regeneration
por: Li, Ying, et al.
Publicado: (2018)

Farnesylation-defective Rheb Increases Axonal Length Independently of mTORC1 Activity in Embryonic Primary Neurons
por: Choi, Seunghyuk, et al.
Publicado: (2019)

Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1
por: Kim, Hyun Ji, et al.
Publicado: (2017)

Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration
por: Sahoo, Pabitra K., et al.
Publicado: (2018)

Promotion of axon regeneration and protection on injured retinal ganglion cells by rCXCL2
por: Zhang, Zi-Yuan, et al.
Publicado: (2023)

Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons
por: Schöneborn, Hendrik, et al.
Publicado: (2018)

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy depletion-induced suppression of mTORC1
por: Zheng, Min, et al.
Publicado: (2011)

Structural Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
por: Yang, Haijuan, et al.
Publicado: (2017)

Drosophila grimshawi – Rheb
por: Rele, Chinmay P., et al.
Publicado: (2021)

Optical coherence tomography evaluation of choroidal structure changes in diabetic retinopathy patients: A systematic review and meta-analysis
por: Jiang, Jikuan, et al.
Publicado: (2022)

Neuroinflammation, Microglia and Implications for Retinal Ganglion Cell Survival and Axon Regeneration in Traumatic Optic Neuropathy
por: Au, Ngan Pan Bennett, et al.
Publicado: (2022)

Dual leucine zipper kinase is necessary for retinal ganglion cell axonal regeneration in Xenopus laevis
por: Fague, Lindsay, et al.
Publicado: (2023)

RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity
por: Proietti Onori, Martina, et al.
Publicado: (2021)

Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells
por: Koch, Jan Christoph, et al.
Publicado: (2014)

Cdk5 Phosphorylation of STAT3 in Dorsal Root Ganglion Neurons Is Involved in Promoting Axonal Regeneration After Peripheral Nerve Injury
por: Hwang, Jinyeon, et al.
Publicado: (2020)

Role of RHEB in Regulating Differentiation Fate of Mesenchymal Stem Cells for Cartilage and Bone Regeneration
por: Ashraf, Sajjad, et al.
Publicado: (2017)

Reproducible generation of human retinal ganglion cells from banked retinal progenitor cells: analysis of target recognition and IGF-1-mediated axon regeneration
por: Subramani, Murali, et al.
Publicado: (2023)

3D Visualization of Individual Regenerating Retinal Ganglion Cell Axons Reveals Surprisingly Complex Growth Paths
por: Bray, Eric R., et al.
Publicado: (2017)

Retinal Ganglion Cell Survival and Axon Regeneration after Optic Nerve Injury: Role of Inflammation and Other Factors
por: Wong, Kimberly A., et al.
Publicado: (2022)

Axonal transport of actin in rabbit retinal ganglion cells
Publicado: (1979)

Extraretinal Spike Normalization in Retinal Ganglion Cell Axons
por: Fogli Iseppe, Alex, et al.
Publicado: (2020)

Lack of CaBP1/Caldendrin or CaBP2 Leads to Altered Ganglion Cell Responses
por: Sinha, Raunak, et al.
Publicado: (2016)

Antiviral immunity rewired for axon regeneration
por: Jiang, Meng, et al.
Publicado: (2023)

On the Generation and Regeneration of Retinal Ganglion Cells
por: Oliveira-Valença, Viviane M., et al.
Publicado: (2020)

Rheb Promotes Triglyceride Secretion and Ameliorates Diet-Induced Steatosis in the Liver
por: Du, Chongyangzi, et al.
Publicado: (2022)

An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation
por: Heard, Jeffrey J., et al.
Publicado: (2018)

Genetic Deletion of Rheb1 in the Brain Reduces Food Intake and Causes Hypoglycemia with Altered Peripheral Metabolism
por: Yang, Wanchun, et al.
Publicado: (2014)

Coordination of Rheb lysosomal membrane interactions with mTORC1 activation
por: Angarola, Brittany, et al.
Publicado: (2020)

Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines
por: Murai, Atsuko, et al.
Publicado: (2012)

Retinal ganglion cell survival and axon regeneration in Wld(S) transgenic rats after optic nerve crush and lens injury
por: Lorber, Barbara, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_o82arqt7ndvr48hrtsokgl7u9u