An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway

BACKGROUND: Sepsis-associated encephalopathy (SAE) is characterized by diffuse brain dysfunction, long-term cognitive impairment, and increased morbidity and mortality. The current treatment for SAE is mainly symptomatic; the lack of specific treatment options and a poor understanding of the underly...

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Detalles Bibliográficos
Autores principales: Liu, Yuqiang, Yang, Han, Luo, Nanbo, Fu, Yifei, Qiu, Fang, Pan, Zhenglong, Li, Xiongjuan, Jian, Wenling, Yang, Xinping, Xue, Qingsheng, Luo, Yan, Yu, Buwei, Liu, Zhiheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360347/
https://www.ncbi.nlm.nih.gov/pubmed/37475042
http://dx.doi.org/10.1186/s12967-023-04345-7

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