Cargando…

Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and Management Strategies

BACKGROUND: With the expanding understanding of conditions contributing to heightened cardiovascular risk, emerging pathologies like nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are being recognized as hepatic and ovarian manifestations of metabolic syndrome, respect...

Descripción completa

Detalles Bibliográficos
Autores principales: Półkośnik, Kinga, Łebkowska, Agnieszka, Kowalska, Irina, Lebensztejn, Dariusz M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360446/
https://www.ncbi.nlm.nih.gov/pubmed/37455412
http://dx.doi.org/10.12659/MSM.940398
_version_ 1785076105205514240
author Półkośnik, Kinga
Łebkowska, Agnieszka
Kowalska, Irina
Lebensztejn, Dariusz M.
author_facet Półkośnik, Kinga
Łebkowska, Agnieszka
Kowalska, Irina
Lebensztejn, Dariusz M.
author_sort Półkośnik, Kinga
collection PubMed
description BACKGROUND: With the expanding understanding of conditions contributing to heightened cardiovascular risk, emerging pathologies like nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are being recognized as hepatic and ovarian manifestations of metabolic syndrome, respectively. This study aims to elucidate the recent advancements in our comprehension of the link between these conditions in the pediatric demographic, focusing on pathogenesis, incidence, diagnostic methods, and effective therapeutic strategies. MATERIAL/METHODS: A systematic review was conducted by searching the PubMed database for eligible original studies published in the 10-year period prior to January 2023 (2013–2022). RESULTS: Out of 23 reports based on 16 original studies, we found a significantly higher prevalence of NAFLD in adolescents with PCOS compared to healthy controls. Factors such as increased de novo lipogenesis, alterations in gut microbiota, and a deficiency in growth differentiation factor-15 have been implicated in their pathogenesis. Additionally, novel biomarker S100A4, a clinical prediction score for hepatic steatosis in PCOS, and pharmacotherapy involving low-dose spironolactone, pioglitazone, and metformin have been proposed to enhance the management of these conditions. CONCLUSIONS: A meticulous approach to the prevention, detection, and treatment of NAFLD in adolescents with PCOS is paramount to mitigate further complications. The study underlines the need for ongoing research to refine our understanding and management of these interconnected metabolic disorders.
format Online
Article
Text
id pubmed-10360446
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-103604462023-07-22 Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and Management Strategies Półkośnik, Kinga Łebkowska, Agnieszka Kowalska, Irina Lebensztejn, Dariusz M. Med Sci Monit Meta-Analysis BACKGROUND: With the expanding understanding of conditions contributing to heightened cardiovascular risk, emerging pathologies like nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are being recognized as hepatic and ovarian manifestations of metabolic syndrome, respectively. This study aims to elucidate the recent advancements in our comprehension of the link between these conditions in the pediatric demographic, focusing on pathogenesis, incidence, diagnostic methods, and effective therapeutic strategies. MATERIAL/METHODS: A systematic review was conducted by searching the PubMed database for eligible original studies published in the 10-year period prior to January 2023 (2013–2022). RESULTS: Out of 23 reports based on 16 original studies, we found a significantly higher prevalence of NAFLD in adolescents with PCOS compared to healthy controls. Factors such as increased de novo lipogenesis, alterations in gut microbiota, and a deficiency in growth differentiation factor-15 have been implicated in their pathogenesis. Additionally, novel biomarker S100A4, a clinical prediction score for hepatic steatosis in PCOS, and pharmacotherapy involving low-dose spironolactone, pioglitazone, and metformin have been proposed to enhance the management of these conditions. CONCLUSIONS: A meticulous approach to the prevention, detection, and treatment of NAFLD in adolescents with PCOS is paramount to mitigate further complications. The study underlines the need for ongoing research to refine our understanding and management of these interconnected metabolic disorders. International Scientific Literature, Inc. 2023-07-17 /pmc/articles/PMC10360446/ /pubmed/37455412 http://dx.doi.org/10.12659/MSM.940398 Text en © Med Sci Monit, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Meta-Analysis
Półkośnik, Kinga
Łebkowska, Agnieszka
Kowalska, Irina
Lebensztejn, Dariusz M.
Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and Management Strategies
title Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and Management Strategies
title_full Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and Management Strategies
title_fullStr Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and Management Strategies
title_full_unstemmed Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and Management Strategies
title_short Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and Management Strategies
title_sort unraveling the interplay between nonalcoholic fatty liver disease and polycystic ovary syndrome in adolescents: pathogenesis, prevalence, and management strategies
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360446/
https://www.ncbi.nlm.nih.gov/pubmed/37455412
http://dx.doi.org/10.12659/MSM.940398
work_keys_str_mv AT połkosnikkinga unravelingtheinterplaybetweennonalcoholicfattyliverdiseaseandpolycysticovarysyndromeinadolescentspathogenesisprevalenceandmanagementstrategies
AT łebkowskaagnieszka unravelingtheinterplaybetweennonalcoholicfattyliverdiseaseandpolycysticovarysyndromeinadolescentspathogenesisprevalenceandmanagementstrategies
AT kowalskairina unravelingtheinterplaybetweennonalcoholicfattyliverdiseaseandpolycysticovarysyndromeinadolescentspathogenesisprevalenceandmanagementstrategies
AT lebensztejndariuszm unravelingtheinterplaybetweennonalcoholicfattyliverdiseaseandpolycysticovarysyndromeinadolescentspathogenesisprevalenceandmanagementstrategies