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Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination
The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. Within an international randomised trial (‘BCG vaccination to reduce the impact of coron...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360588/ https://www.ncbi.nlm.nih.gov/pubmed/37484338 http://dx.doi.org/10.1016/j.heliyon.2023.e15821 |
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author | Villanueva, Paola Crawford, Nigel W. Croda, Mariana Garcia Collopy, Simone Jardim, Bruno Araújo de Almeida Pinto Jardim, Tyane Manning, Laurens Lucas, Michaela Marshall, Helen Prat-Aymerich, Cristina Sawka, Alice Sharma, Ketaki Troeman, Darren Wadia, Ushma Warris, Adilia Wood, Nicholas Messina, Nicole L. Curtis, Nigel Pittet, Laure F. |
author_facet | Villanueva, Paola Crawford, Nigel W. Croda, Mariana Garcia Collopy, Simone Jardim, Bruno Araújo de Almeida Pinto Jardim, Tyane Manning, Laurens Lucas, Michaela Marshall, Helen Prat-Aymerich, Cristina Sawka, Alice Sharma, Ketaki Troeman, Darren Wadia, Ushma Warris, Adilia Wood, Nicholas Messina, Nicole L. Curtis, Nigel Pittet, Laure F. |
author_sort | Villanueva, Paola |
collection | PubMed |
description | The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. Within an international randomised trial (‘BCG vaccination to reduce the impact of coronavirus disease 2019 (COVID-19) in healthcare workers’; BRACE Trial), this nested prospective cohort study assessed the prevalence of and factors influencing scar formation, as well as participant perception of BCG scarring 12 months following vaccination. Amongst 3071 BCG-recipients, 2341 (76%) developed a BCG scar. Scar prevalence was lowest in Spain and highest in UK. Absence of post-injection wheal (OR 0.4, 95%CI 0.2–0.9), BCG revaccination (OR 1.7, 95%CI 1.3–2.0), female sex (OR 2.0, 95%CI 1.7–2.4), older age (OR 0.4, 95%CI 0.4–0.5) and study country (Brazil OR 1.6, 95%CI 1.3–2.0) influenced BCG scar prevalence. Of the 2341 participants with a BCG scar, 1806 (77%) did not mind having the scar. Participants more likely to not mind were those in Brazil, males and those with a prior BCG vaccination history. The majority (96%) did not regret having the vaccine. Both vaccination-related (amenable to optimisation) and individual-related factors affected BCG scar prevalence 12 months following BCG vaccination of adults, with implications for maximising the effectiveness of BCG vaccination. |
format | Online Article Text |
id | pubmed-10360588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103605882023-07-22 Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination Villanueva, Paola Crawford, Nigel W. Croda, Mariana Garcia Collopy, Simone Jardim, Bruno Araújo de Almeida Pinto Jardim, Tyane Manning, Laurens Lucas, Michaela Marshall, Helen Prat-Aymerich, Cristina Sawka, Alice Sharma, Ketaki Troeman, Darren Wadia, Ushma Warris, Adilia Wood, Nicholas Messina, Nicole L. Curtis, Nigel Pittet, Laure F. Heliyon Corrigendum The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. Within an international randomised trial (‘BCG vaccination to reduce the impact of coronavirus disease 2019 (COVID-19) in healthcare workers’; BRACE Trial), this nested prospective cohort study assessed the prevalence of and factors influencing scar formation, as well as participant perception of BCG scarring 12 months following vaccination. Amongst 3071 BCG-recipients, 2341 (76%) developed a BCG scar. Scar prevalence was lowest in Spain and highest in UK. Absence of post-injection wheal (OR 0.4, 95%CI 0.2–0.9), BCG revaccination (OR 1.7, 95%CI 1.3–2.0), female sex (OR 2.0, 95%CI 1.7–2.4), older age (OR 0.4, 95%CI 0.4–0.5) and study country (Brazil OR 1.6, 95%CI 1.3–2.0) influenced BCG scar prevalence. Of the 2341 participants with a BCG scar, 1806 (77%) did not mind having the scar. Participants more likely to not mind were those in Brazil, males and those with a prior BCG vaccination history. The majority (96%) did not regret having the vaccine. Both vaccination-related (amenable to optimisation) and individual-related factors affected BCG scar prevalence 12 months following BCG vaccination of adults, with implications for maximising the effectiveness of BCG vaccination. Elsevier 2023-04-26 /pmc/articles/PMC10360588/ /pubmed/37484338 http://dx.doi.org/10.1016/j.heliyon.2023.e15821 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Corrigendum Villanueva, Paola Crawford, Nigel W. Croda, Mariana Garcia Collopy, Simone Jardim, Bruno Araújo de Almeida Pinto Jardim, Tyane Manning, Laurens Lucas, Michaela Marshall, Helen Prat-Aymerich, Cristina Sawka, Alice Sharma, Ketaki Troeman, Darren Wadia, Ushma Warris, Adilia Wood, Nicholas Messina, Nicole L. Curtis, Nigel Pittet, Laure F. Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination |
title | Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination |
title_full | Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination |
title_fullStr | Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination |
title_full_unstemmed | Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination |
title_short | Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination |
title_sort | factors influencing scar formation following bacille calmette-guérin (bcg) vaccination |
topic | Corrigendum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360588/ https://www.ncbi.nlm.nih.gov/pubmed/37484338 http://dx.doi.org/10.1016/j.heliyon.2023.e15821 |
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