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Tongue coating microbiome composition reflects disease severity in patients with COVID-19 in Nanjing, China
Our purpose is to investigate the relationship between the microbiota of patients' tongue coating microbiota and the severity of COVID-19, and to identify the severity of COVID-19 patients' condition as early as possible. The participants were categorized into three groups: healthy control...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360987/ https://www.ncbi.nlm.nih.gov/pubmed/37483641 http://dx.doi.org/10.1080/20002297.2023.2236429 |
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author | Jiang, Zongdan Yang, Lu Qian, Xuetian Su, Kunhan Huang, Yuzhen Qu, Yi Zhang, Zhenyu Liu, Wanli |
author_facet | Jiang, Zongdan Yang, Lu Qian, Xuetian Su, Kunhan Huang, Yuzhen Qu, Yi Zhang, Zhenyu Liu, Wanli |
author_sort | Jiang, Zongdan |
collection | PubMed |
description | Our purpose is to investigate the relationship between the microbiota of patients' tongue coating microbiota and the severity of COVID-19, and to identify the severity of COVID-19 patients' condition as early as possible. The participants were categorized into three groups: healthy controls (Con group) consisting of 37 individuals, patients with mild to moderate symptoms (M group) comprising 49 individuals, and patients with severe and critical symptoms (S-C group) consisting of 44 individuals. We collected oral swabs from all participants and performed 16S rRNA gene sequencing to analyze the microbiome. The α and β diversity differences were assessed respectively. Additionally, we employed the Linear Discriminant Analysis Effect Size (LEfSe) analysis to evaluate taxonomic differences among the three groups. Our findings revealed a significantly higher richness of tongue coating microbiota in both the S-C group and M group compared to the Con group. When compared with Con group, decreased Prevotella, Neisseria, Fusobacterium and Alloprevotella, and over-expressed Streptococcus and Rothia in M and S-C group were identified. LEfSe analysis indicated a greater abundance of Pseudomonas, Acinetbacter, Lactobacillus, Corynebacterium, Rothia in S-C group. Our study suggests a potential association between tongue coating microbiome and the severity of COVID-19 patients. |
format | Online Article Text |
id | pubmed-10360987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-103609872023-07-22 Tongue coating microbiome composition reflects disease severity in patients with COVID-19 in Nanjing, China Jiang, Zongdan Yang, Lu Qian, Xuetian Su, Kunhan Huang, Yuzhen Qu, Yi Zhang, Zhenyu Liu, Wanli J Oral Microbiol Original Article Our purpose is to investigate the relationship between the microbiota of patients' tongue coating microbiota and the severity of COVID-19, and to identify the severity of COVID-19 patients' condition as early as possible. The participants were categorized into three groups: healthy controls (Con group) consisting of 37 individuals, patients with mild to moderate symptoms (M group) comprising 49 individuals, and patients with severe and critical symptoms (S-C group) consisting of 44 individuals. We collected oral swabs from all participants and performed 16S rRNA gene sequencing to analyze the microbiome. The α and β diversity differences were assessed respectively. Additionally, we employed the Linear Discriminant Analysis Effect Size (LEfSe) analysis to evaluate taxonomic differences among the three groups. Our findings revealed a significantly higher richness of tongue coating microbiota in both the S-C group and M group compared to the Con group. When compared with Con group, decreased Prevotella, Neisseria, Fusobacterium and Alloprevotella, and over-expressed Streptococcus and Rothia in M and S-C group were identified. LEfSe analysis indicated a greater abundance of Pseudomonas, Acinetbacter, Lactobacillus, Corynebacterium, Rothia in S-C group. Our study suggests a potential association between tongue coating microbiome and the severity of COVID-19 patients. Taylor & Francis 2023-07-19 /pmc/articles/PMC10360987/ /pubmed/37483641 http://dx.doi.org/10.1080/20002297.2023.2236429 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
spellingShingle | Original Article Jiang, Zongdan Yang, Lu Qian, Xuetian Su, Kunhan Huang, Yuzhen Qu, Yi Zhang, Zhenyu Liu, Wanli Tongue coating microbiome composition reflects disease severity in patients with COVID-19 in Nanjing, China |
title | Tongue coating microbiome composition reflects disease severity in patients with COVID-19 in Nanjing, China |
title_full | Tongue coating microbiome composition reflects disease severity in patients with COVID-19 in Nanjing, China |
title_fullStr | Tongue coating microbiome composition reflects disease severity in patients with COVID-19 in Nanjing, China |
title_full_unstemmed | Tongue coating microbiome composition reflects disease severity in patients with COVID-19 in Nanjing, China |
title_short | Tongue coating microbiome composition reflects disease severity in patients with COVID-19 in Nanjing, China |
title_sort | tongue coating microbiome composition reflects disease severity in patients with covid-19 in nanjing, china |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360987/ https://www.ncbi.nlm.nih.gov/pubmed/37483641 http://dx.doi.org/10.1080/20002297.2023.2236429 |
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