Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, and in silico insights

This research study describes the development of new small molecules based on 2,4-thiazolidinedione (2,4-TZD) and their aldose reductase (AR) inhibitory activities. The synthesis of 17 new derivatives of 2,4-TZDs hybrids was feasible by incorporating two known bioactive scaffolds, benzothiazole hete...

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Detalles Bibliográficos
Autores principales: Hamdi, Abdelrahman, Yaseen, Muhammad, Ewes, Wafaa A., Bhat, Mashooq Ahmad, Ziedan, Noha I., El-Shafey, Hamed W., Mohamed, Ahmed A. B., Elnagar, Mohamed R., Haikal, Abdullah, Othman, Dina I. A., Elgazar, Abdullah A., Abusabaa, Ahmed H. A., Abdelrahman, Kamal S., Soltan, Osama M., Elbadawi, Mostafa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361003/
https://www.ncbi.nlm.nih.gov/pubmed/37470409
http://dx.doi.org/10.1080/14756366.2023.2231170

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