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Safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars

IMPORTANCE: It is necessary to determine whether safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars. OBJECTIVE: To identify autologous skin tissue cells grafting can reduce facial sunken or flat scars. DESIGN, SETTING, AND PARTICIPANTS: In this retrospective...

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Detalles Bibliográficos
Autores principales: Liu, Tao, Chen, Jinxi, Wei, Bin, Nie, Fangfang, Zhu, Guanghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361016/
https://www.ncbi.nlm.nih.gov/pubmed/37484283
http://dx.doi.org/10.1016/j.heliyon.2023.e16992
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author Liu, Tao
Chen, Jinxi
Wei, Bin
Nie, Fangfang
Zhu, Guanghui
author_facet Liu, Tao
Chen, Jinxi
Wei, Bin
Nie, Fangfang
Zhu, Guanghui
author_sort Liu, Tao
collection PubMed
description IMPORTANCE: It is necessary to determine whether safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars. OBJECTIVE: To identify autologous skin tissue cells grafting can reduce facial sunken or flat scars. DESIGN, SETTING, AND PARTICIPANTS: In this retrospective cross-sectional study, a total of 128 patients with scar (exclude pathological scar patients), who were receiving autologous skin tissue cells grafting therapy from January 1, 2016, to December 31, 2019. INTERVENTIONS: Autologous skin tissue cells grafting. MAIN OUTCOMES AND MEASURES: Changes in scar severity, color changes in the scar area, infection rate and patient satisfaction. RESULTS: A total of 128 patients with scar (89 females [69.5%]; mean [SD] age, 30.6 [13.12] years) received autologous skin tissue cells grafting therapy. SCAR (Scar Cosmesis Assessment and Rating), with scores ranging from 0 (best possible scar) to 15 (worst possible scar). After treatment 12 months, the mean [SD] of SCAR score went down from 9.85 [1.33] to 2.67 [1.21]. No infection was observed during treatment or recovery, and the main drawback after autologous skin tissue cells grafting is that the color recovery time is longer. The patient satisfaction 6 months after treatment was 85.2%, furthermore 12 months after treatment patient satisfaction was 94.7%. CONCLUSIONS AND RELEVANCE: In this study, autologous skin tissue cells grafting was safe and effective to treat facial scars. Therefore, autologous skin tissue cells grafting may be recommended as a reliable treatment for facial scar.
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spelling pubmed-103610162023-07-22 Safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars Liu, Tao Chen, Jinxi Wei, Bin Nie, Fangfang Zhu, Guanghui Heliyon Research Article IMPORTANCE: It is necessary to determine whether safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars. OBJECTIVE: To identify autologous skin tissue cells grafting can reduce facial sunken or flat scars. DESIGN, SETTING, AND PARTICIPANTS: In this retrospective cross-sectional study, a total of 128 patients with scar (exclude pathological scar patients), who were receiving autologous skin tissue cells grafting therapy from January 1, 2016, to December 31, 2019. INTERVENTIONS: Autologous skin tissue cells grafting. MAIN OUTCOMES AND MEASURES: Changes in scar severity, color changes in the scar area, infection rate and patient satisfaction. RESULTS: A total of 128 patients with scar (89 females [69.5%]; mean [SD] age, 30.6 [13.12] years) received autologous skin tissue cells grafting therapy. SCAR (Scar Cosmesis Assessment and Rating), with scores ranging from 0 (best possible scar) to 15 (worst possible scar). After treatment 12 months, the mean [SD] of SCAR score went down from 9.85 [1.33] to 2.67 [1.21]. No infection was observed during treatment or recovery, and the main drawback after autologous skin tissue cells grafting is that the color recovery time is longer. The patient satisfaction 6 months after treatment was 85.2%, furthermore 12 months after treatment patient satisfaction was 94.7%. CONCLUSIONS AND RELEVANCE: In this study, autologous skin tissue cells grafting was safe and effective to treat facial scars. Therefore, autologous skin tissue cells grafting may be recommended as a reliable treatment for facial scar. Elsevier 2023-06-07 /pmc/articles/PMC10361016/ /pubmed/37484283 http://dx.doi.org/10.1016/j.heliyon.2023.e16992 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Liu, Tao
Chen, Jinxi
Wei, Bin
Nie, Fangfang
Zhu, Guanghui
Safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars
title Safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars
title_full Safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars
title_fullStr Safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars
title_full_unstemmed Safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars
title_short Safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars
title_sort safety and efficacy of autologous skin tissue cells grafting for facial sunken or flat scars
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361016/
https://www.ncbi.nlm.nih.gov/pubmed/37484283
http://dx.doi.org/10.1016/j.heliyon.2023.e16992
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