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Immune responses in the uterine mucosa: clues for vaccine development in pigs

The immune system in the upper reproductive tract (URT) protects against sexually transmitted pathogens, while at the same time providing immune tolerance responses against allogenic sperm and the developing fetus. The uterine environment is also responsive to hormonal variations during the estrus c...

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Autores principales: Choudhary, Pooja, Magloire, Donaldson, Hamonic, Glenn, Wilson, Heather L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361056/
https://www.ncbi.nlm.nih.gov/pubmed/37483639
http://dx.doi.org/10.3389/fimmu.2023.1171212
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author Choudhary, Pooja
Magloire, Donaldson
Hamonic, Glenn
Wilson, Heather L.
author_facet Choudhary, Pooja
Magloire, Donaldson
Hamonic, Glenn
Wilson, Heather L.
author_sort Choudhary, Pooja
collection PubMed
description The immune system in the upper reproductive tract (URT) protects against sexually transmitted pathogens, while at the same time providing immune tolerance responses against allogenic sperm and the developing fetus. The uterine environment is also responsive to hormonal variations during the estrus cycle, although the most likely timing of exposure to pathogens is during estrus and breeding when the cervix is semi-permissive. The goal for intrauterine immunization would be to induce local or systemic immunity and/or to promote colostral/lactogenic immunity that will passively protect suckling offspring. The developing fetus is not the vaccine target. This minireview article focuses on the immune response induced in the pig uterus (uterine body and uterine horns) with some comparative references to other livestock species, mice, and humans.
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spelling pubmed-103610562023-07-22 Immune responses in the uterine mucosa: clues for vaccine development in pigs Choudhary, Pooja Magloire, Donaldson Hamonic, Glenn Wilson, Heather L. Front Immunol Immunology The immune system in the upper reproductive tract (URT) protects against sexually transmitted pathogens, while at the same time providing immune tolerance responses against allogenic sperm and the developing fetus. The uterine environment is also responsive to hormonal variations during the estrus cycle, although the most likely timing of exposure to pathogens is during estrus and breeding when the cervix is semi-permissive. The goal for intrauterine immunization would be to induce local or systemic immunity and/or to promote colostral/lactogenic immunity that will passively protect suckling offspring. The developing fetus is not the vaccine target. This minireview article focuses on the immune response induced in the pig uterus (uterine body and uterine horns) with some comparative references to other livestock species, mice, and humans. Frontiers Media S.A. 2023-07-07 /pmc/articles/PMC10361056/ /pubmed/37483639 http://dx.doi.org/10.3389/fimmu.2023.1171212 Text en Copyright © 2023 Choudhary, Magloire, Hamonic and Wilson https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Choudhary, Pooja
Magloire, Donaldson
Hamonic, Glenn
Wilson, Heather L.
Immune responses in the uterine mucosa: clues for vaccine development in pigs
title Immune responses in the uterine mucosa: clues for vaccine development in pigs
title_full Immune responses in the uterine mucosa: clues for vaccine development in pigs
title_fullStr Immune responses in the uterine mucosa: clues for vaccine development in pigs
title_full_unstemmed Immune responses in the uterine mucosa: clues for vaccine development in pigs
title_short Immune responses in the uterine mucosa: clues for vaccine development in pigs
title_sort immune responses in the uterine mucosa: clues for vaccine development in pigs
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361056/
https://www.ncbi.nlm.nih.gov/pubmed/37483639
http://dx.doi.org/10.3389/fimmu.2023.1171212
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