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CDK4/6 inhibition confers protection of normal gut epithelia against gemcitabine and the active metabolite of irinotecan

Cancer chemotherapy relies on a high ratio of toxicity toward cancer cells vs. nonmalignant cells, making it desirable to protect normal cells. Among the nonmalignant cells, epithelia of the gut belong to the most vulnerable ones toward chemotherapeutics. Here, we use a murine intestinal organoid mo...

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Detalles Bibliográficos
Autores principales:	Blume, Joshua, Claus, Luisa, Isermann, Tamara, Dickmanns, Antje, Conradi, Lena-Christin, Schulz-Heddergott, Ramona, Dobbelstein, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361147/ https://www.ncbi.nlm.nih.gov/pubmed/37266562 http://dx.doi.org/10.1080/15384101.2023.2217003

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