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Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes

In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes. During S-phase, only a subset of origins is selected in a stochastic manner to assemble bidirectional replication forks and initiate DNA synthes...

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Detalles Bibliográficos
Autores principales: Lee, Clare S.K., Weiβ, Matthias, Hamperl, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361152/
https://www.ncbi.nlm.nih.gov/pubmed/37469113
http://dx.doi.org/10.1080/19491034.2023.2229642
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author Lee, Clare S.K.
Weiβ, Matthias
Hamperl, Stephan
author_facet Lee, Clare S.K.
Weiβ, Matthias
Hamperl, Stephan
author_sort Lee, Clare S.K.
collection PubMed
description In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes. During S-phase, only a subset of origins is selected in a stochastic manner to assemble bidirectional replication forks and initiate DNA synthesis. Despite substantial progress in our understanding of this complex process, a comprehensive ‘identity code’ that defines origins based on specific nucleotide sequences, DNA structural features, the local chromatin environment, or 3D genome architecture is still missing. In this article, we review the genetic and epigenetic features of replication origins in yeast and metazoan chromosomes and highlight recent insights into how this flexibility in origin usage contributes to nuclear organization, cell growth, differentiation, and genome stability.
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spelling pubmed-103611522023-07-22 Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes Lee, Clare S.K. Weiβ, Matthias Hamperl, Stephan Nucleus Research Paper In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes. During S-phase, only a subset of origins is selected in a stochastic manner to assemble bidirectional replication forks and initiate DNA synthesis. Despite substantial progress in our understanding of this complex process, a comprehensive ‘identity code’ that defines origins based on specific nucleotide sequences, DNA structural features, the local chromatin environment, or 3D genome architecture is still missing. In this article, we review the genetic and epigenetic features of replication origins in yeast and metazoan chromosomes and highlight recent insights into how this flexibility in origin usage contributes to nuclear organization, cell growth, differentiation, and genome stability. Taylor & Francis 2023-07-19 /pmc/articles/PMC10361152/ /pubmed/37469113 http://dx.doi.org/10.1080/19491034.2023.2229642 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Research Paper
Lee, Clare S.K.
Weiβ, Matthias
Hamperl, Stephan
Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes
title Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes
title_full Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes
title_fullStr Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes
title_full_unstemmed Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes
title_short Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes
title_sort where and when to start: regulating dna replication origin activity in eukaryotic genomes
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361152/
https://www.ncbi.nlm.nih.gov/pubmed/37469113
http://dx.doi.org/10.1080/19491034.2023.2229642
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