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The characteristic of stem-related genes with pancreatic carcinoma cell after irradiation
PURPOSE: To investigate stem-related differentially expressed genes (DEGs) and their potential mechanism in pancreatic cancer cells (MIAPaCa-2) exposed to x-ray and proton radiation, as well as how these factors affected the prognosis of patients with pancreatic adenocarcinoma (PADC). METHODS: The s...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361223/ https://www.ncbi.nlm.nih.gov/pubmed/37484310 http://dx.doi.org/10.1016/j.heliyon.2023.e17074 |
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author | Luo, Yunxiu |
author_facet | Luo, Yunxiu |
author_sort | Luo, Yunxiu |
collection | PubMed |
description | PURPOSE: To investigate stem-related differentially expressed genes (DEGs) and their potential mechanism in pancreatic cancer cells (MIAPaCa-2) exposed to x-ray and proton radiation, as well as how these factors affected the prognosis of patients with pancreatic adenocarcinoma (PADC). METHODS: The stem-related DEGs were screened using the online tool Stemchecker after protons and x-rays were used to irradiate MIAPaCa-2 cells. Analysis was done on the probable processes and prognostic significance of the DEGs in PAC patients. RESULTS: Four datasets containing 401 DEGs were filtered, and the stem-related DEGs for each irradiation type indicated a variety of radiobiological characteristics. In pancreatic cancer cells, a number of stem-related DEGs may serve as biomarkers of radiation effects. Patients with pancreatic cancer demonstrated predictive significance for GRB7, B2M, and PMAIP1. CONCLUSIONS: MIAPaCa-2 cells exposed to x-rays and protons repeatedly displayed heterogeneous expression of stem-related DEGs involved in complex radiosensitivity, radio-resistance, and radio-induced mortality pathways. GRB7 and B2M were considered potential radiation sensitivity indicators for pancreatic cancer. |
format | Online Article Text |
id | pubmed-10361223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103612232023-07-22 The characteristic of stem-related genes with pancreatic carcinoma cell after irradiation Luo, Yunxiu Heliyon Research Article PURPOSE: To investigate stem-related differentially expressed genes (DEGs) and their potential mechanism in pancreatic cancer cells (MIAPaCa-2) exposed to x-ray and proton radiation, as well as how these factors affected the prognosis of patients with pancreatic adenocarcinoma (PADC). METHODS: The stem-related DEGs were screened using the online tool Stemchecker after protons and x-rays were used to irradiate MIAPaCa-2 cells. Analysis was done on the probable processes and prognostic significance of the DEGs in PAC patients. RESULTS: Four datasets containing 401 DEGs were filtered, and the stem-related DEGs for each irradiation type indicated a variety of radiobiological characteristics. In pancreatic cancer cells, a number of stem-related DEGs may serve as biomarkers of radiation effects. Patients with pancreatic cancer demonstrated predictive significance for GRB7, B2M, and PMAIP1. CONCLUSIONS: MIAPaCa-2 cells exposed to x-rays and protons repeatedly displayed heterogeneous expression of stem-related DEGs involved in complex radiosensitivity, radio-resistance, and radio-induced mortality pathways. GRB7 and B2M were considered potential radiation sensitivity indicators for pancreatic cancer. Elsevier 2023-06-08 /pmc/articles/PMC10361223/ /pubmed/37484310 http://dx.doi.org/10.1016/j.heliyon.2023.e17074 Text en © 2023 The Author https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Luo, Yunxiu The characteristic of stem-related genes with pancreatic carcinoma cell after irradiation |
title | The characteristic of stem-related genes with pancreatic carcinoma cell after irradiation |
title_full | The characteristic of stem-related genes with pancreatic carcinoma cell after irradiation |
title_fullStr | The characteristic of stem-related genes with pancreatic carcinoma cell after irradiation |
title_full_unstemmed | The characteristic of stem-related genes with pancreatic carcinoma cell after irradiation |
title_short | The characteristic of stem-related genes with pancreatic carcinoma cell after irradiation |
title_sort | characteristic of stem-related genes with pancreatic carcinoma cell after irradiation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361223/ https://www.ncbi.nlm.nih.gov/pubmed/37484310 http://dx.doi.org/10.1016/j.heliyon.2023.e17074 |
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