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Jujuboside B suppresses angiogenesis and tumor growth via blocking VEGFR2 signaling pathway
Jujuboside B (JuB), one of the main active triterpenoid saponins from the traditional Chinese medicine Ziziphus jujuba, possesses a wide range of pharmacological activities. However, it is unknown whether JuB can inhibit tumor angiogenesis, a crucial step in solid tumor growth. In this study, we fou...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361242/ https://www.ncbi.nlm.nih.gov/pubmed/37484305 http://dx.doi.org/10.1016/j.heliyon.2023.e17072 |
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author | Zhang, Pan Lai, Xing Zhu, Mao-Hua Shi, Jiangpei Pan, Hong Huang, Yanhu Guo, Run-Jie Lu, Qin Fang, Chao Zhao, Mei |
author_facet | Zhang, Pan Lai, Xing Zhu, Mao-Hua Shi, Jiangpei Pan, Hong Huang, Yanhu Guo, Run-Jie Lu, Qin Fang, Chao Zhao, Mei |
author_sort | Zhang, Pan |
collection | PubMed |
description | Jujuboside B (JuB), one of the main active triterpenoid saponins from the traditional Chinese medicine Ziziphus jujuba, possesses a wide range of pharmacological activities. However, it is unknown whether JuB can inhibit tumor angiogenesis, a crucial step in solid tumor growth. In this study, we found that JuB significantly inhibited the proliferation, migration, and tube formation of human umbilical vein endothelial cells in a dose-dependent manner. JuB also suppressed angiogenesis in chick embryo chorioallantoic membranes and Matrigel plugs. Moreover, through angiogenesis inhibition, JuB delayed the growth of human HCT-15 colorectal cancer xenograft in mice. Western blot assay demonstrated that JuB inhibited the phosphorylation of VEGFR2 and its key downstream protein kinases, such as Akt, FAK, Src, and PLCγ1. In conclusion, the antiangiogenic potency and molecular mechanism of JuB are revealed for the first time, indicating that this triterpene saponin may be further explored as a potential drug candidate or lead compound for antiangiogenic cancer therapy. |
format | Online Article Text |
id | pubmed-10361242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103612422023-07-22 Jujuboside B suppresses angiogenesis and tumor growth via blocking VEGFR2 signaling pathway Zhang, Pan Lai, Xing Zhu, Mao-Hua Shi, Jiangpei Pan, Hong Huang, Yanhu Guo, Run-Jie Lu, Qin Fang, Chao Zhao, Mei Heliyon Research Article Jujuboside B (JuB), one of the main active triterpenoid saponins from the traditional Chinese medicine Ziziphus jujuba, possesses a wide range of pharmacological activities. However, it is unknown whether JuB can inhibit tumor angiogenesis, a crucial step in solid tumor growth. In this study, we found that JuB significantly inhibited the proliferation, migration, and tube formation of human umbilical vein endothelial cells in a dose-dependent manner. JuB also suppressed angiogenesis in chick embryo chorioallantoic membranes and Matrigel plugs. Moreover, through angiogenesis inhibition, JuB delayed the growth of human HCT-15 colorectal cancer xenograft in mice. Western blot assay demonstrated that JuB inhibited the phosphorylation of VEGFR2 and its key downstream protein kinases, such as Akt, FAK, Src, and PLCγ1. In conclusion, the antiangiogenic potency and molecular mechanism of JuB are revealed for the first time, indicating that this triterpene saponin may be further explored as a potential drug candidate or lead compound for antiangiogenic cancer therapy. Elsevier 2023-06-07 /pmc/articles/PMC10361242/ /pubmed/37484305 http://dx.doi.org/10.1016/j.heliyon.2023.e17072 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Zhang, Pan Lai, Xing Zhu, Mao-Hua Shi, Jiangpei Pan, Hong Huang, Yanhu Guo, Run-Jie Lu, Qin Fang, Chao Zhao, Mei Jujuboside B suppresses angiogenesis and tumor growth via blocking VEGFR2 signaling pathway |
title | Jujuboside B suppresses angiogenesis and tumor growth via blocking VEGFR2 signaling pathway |
title_full | Jujuboside B suppresses angiogenesis and tumor growth via blocking VEGFR2 signaling pathway |
title_fullStr | Jujuboside B suppresses angiogenesis and tumor growth via blocking VEGFR2 signaling pathway |
title_full_unstemmed | Jujuboside B suppresses angiogenesis and tumor growth via blocking VEGFR2 signaling pathway |
title_short | Jujuboside B suppresses angiogenesis and tumor growth via blocking VEGFR2 signaling pathway |
title_sort | jujuboside b suppresses angiogenesis and tumor growth via blocking vegfr2 signaling pathway |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361242/ https://www.ncbi.nlm.nih.gov/pubmed/37484305 http://dx.doi.org/10.1016/j.heliyon.2023.e17072 |
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