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Hypoxia inducible factor-1α is an important regulator of macrophage biology

Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate various immune responses. HIF-1α regulates th...

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Autores principales: Qiu, Bingquan, Yuan, Piaoliu, Du, Xiaojuan, Jin, Hongfang, Du, Junbao, Huang, Yaqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361316/
https://www.ncbi.nlm.nih.gov/pubmed/37484306
http://dx.doi.org/10.1016/j.heliyon.2023.e17167
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author Qiu, Bingquan
Yuan, Piaoliu
Du, Xiaojuan
Jin, Hongfang
Du, Junbao
Huang, Yaqian
author_facet Qiu, Bingquan
Yuan, Piaoliu
Du, Xiaojuan
Jin, Hongfang
Du, Junbao
Huang, Yaqian
author_sort Qiu, Bingquan
collection PubMed
description Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate various immune responses. HIF-1α regulates the immune response, viability, migration, phenotypic plasticity, and metabolism of macrophages. Specifically, macrophage-derived HIF-1α can prevent excessive pro-inflammatory responses by attenuating the transcriptional activity of nuclear factor-kappa B in vivo and in vitro. HIF-1α modulates macrophage migration by inducing the release of various chemokines and providing necessary energy. HIF-1α promotes macrophage M1 polarization by targeting glucose metabolism. Additionally, HIF-1α induces the upregulation of glycolysis-related enzymes and intermediates of the tricarboxylic acid cycle and pentose phosphate pathway. HIF-1α promotes macrophage apoptosis, necroptosis and reduces autophagy. The current review highlights the mechanisms associated with the regulation of HIF-1α stabilization in macrophages as well as the role of HIF-1α in modulating the physiological functions of macrophages.
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spelling pubmed-103613162023-07-22 Hypoxia inducible factor-1α is an important regulator of macrophage biology Qiu, Bingquan Yuan, Piaoliu Du, Xiaojuan Jin, Hongfang Du, Junbao Huang, Yaqian Heliyon Review Article Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate various immune responses. HIF-1α regulates the immune response, viability, migration, phenotypic plasticity, and metabolism of macrophages. Specifically, macrophage-derived HIF-1α can prevent excessive pro-inflammatory responses by attenuating the transcriptional activity of nuclear factor-kappa B in vivo and in vitro. HIF-1α modulates macrophage migration by inducing the release of various chemokines and providing necessary energy. HIF-1α promotes macrophage M1 polarization by targeting glucose metabolism. Additionally, HIF-1α induces the upregulation of glycolysis-related enzymes and intermediates of the tricarboxylic acid cycle and pentose phosphate pathway. HIF-1α promotes macrophage apoptosis, necroptosis and reduces autophagy. The current review highlights the mechanisms associated with the regulation of HIF-1α stabilization in macrophages as well as the role of HIF-1α in modulating the physiological functions of macrophages. Elsevier 2023-06-09 /pmc/articles/PMC10361316/ /pubmed/37484306 http://dx.doi.org/10.1016/j.heliyon.2023.e17167 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Qiu, Bingquan
Yuan, Piaoliu
Du, Xiaojuan
Jin, Hongfang
Du, Junbao
Huang, Yaqian
Hypoxia inducible factor-1α is an important regulator of macrophage biology
title Hypoxia inducible factor-1α is an important regulator of macrophage biology
title_full Hypoxia inducible factor-1α is an important regulator of macrophage biology
title_fullStr Hypoxia inducible factor-1α is an important regulator of macrophage biology
title_full_unstemmed Hypoxia inducible factor-1α is an important regulator of macrophage biology
title_short Hypoxia inducible factor-1α is an important regulator of macrophage biology
title_sort hypoxia inducible factor-1α is an important regulator of macrophage biology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361316/
https://www.ncbi.nlm.nih.gov/pubmed/37484306
http://dx.doi.org/10.1016/j.heliyon.2023.e17167
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