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Hypoxia inducible factor-1α is an important regulator of macrophage biology
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate various immune responses. HIF-1α regulates th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361316/ https://www.ncbi.nlm.nih.gov/pubmed/37484306 http://dx.doi.org/10.1016/j.heliyon.2023.e17167 |
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author | Qiu, Bingquan Yuan, Piaoliu Du, Xiaojuan Jin, Hongfang Du, Junbao Huang, Yaqian |
author_facet | Qiu, Bingquan Yuan, Piaoliu Du, Xiaojuan Jin, Hongfang Du, Junbao Huang, Yaqian |
author_sort | Qiu, Bingquan |
collection | PubMed |
description | Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate various immune responses. HIF-1α regulates the immune response, viability, migration, phenotypic plasticity, and metabolism of macrophages. Specifically, macrophage-derived HIF-1α can prevent excessive pro-inflammatory responses by attenuating the transcriptional activity of nuclear factor-kappa B in vivo and in vitro. HIF-1α modulates macrophage migration by inducing the release of various chemokines and providing necessary energy. HIF-1α promotes macrophage M1 polarization by targeting glucose metabolism. Additionally, HIF-1α induces the upregulation of glycolysis-related enzymes and intermediates of the tricarboxylic acid cycle and pentose phosphate pathway. HIF-1α promotes macrophage apoptosis, necroptosis and reduces autophagy. The current review highlights the mechanisms associated with the regulation of HIF-1α stabilization in macrophages as well as the role of HIF-1α in modulating the physiological functions of macrophages. |
format | Online Article Text |
id | pubmed-10361316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103613162023-07-22 Hypoxia inducible factor-1α is an important regulator of macrophage biology Qiu, Bingquan Yuan, Piaoliu Du, Xiaojuan Jin, Hongfang Du, Junbao Huang, Yaqian Heliyon Review Article Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate various immune responses. HIF-1α regulates the immune response, viability, migration, phenotypic plasticity, and metabolism of macrophages. Specifically, macrophage-derived HIF-1α can prevent excessive pro-inflammatory responses by attenuating the transcriptional activity of nuclear factor-kappa B in vivo and in vitro. HIF-1α modulates macrophage migration by inducing the release of various chemokines and providing necessary energy. HIF-1α promotes macrophage M1 polarization by targeting glucose metabolism. Additionally, HIF-1α induces the upregulation of glycolysis-related enzymes and intermediates of the tricarboxylic acid cycle and pentose phosphate pathway. HIF-1α promotes macrophage apoptosis, necroptosis and reduces autophagy. The current review highlights the mechanisms associated with the regulation of HIF-1α stabilization in macrophages as well as the role of HIF-1α in modulating the physiological functions of macrophages. Elsevier 2023-06-09 /pmc/articles/PMC10361316/ /pubmed/37484306 http://dx.doi.org/10.1016/j.heliyon.2023.e17167 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Qiu, Bingquan Yuan, Piaoliu Du, Xiaojuan Jin, Hongfang Du, Junbao Huang, Yaqian Hypoxia inducible factor-1α is an important regulator of macrophage biology |
title | Hypoxia inducible factor-1α is an important regulator of macrophage biology |
title_full | Hypoxia inducible factor-1α is an important regulator of macrophage biology |
title_fullStr | Hypoxia inducible factor-1α is an important regulator of macrophage biology |
title_full_unstemmed | Hypoxia inducible factor-1α is an important regulator of macrophage biology |
title_short | Hypoxia inducible factor-1α is an important regulator of macrophage biology |
title_sort | hypoxia inducible factor-1α is an important regulator of macrophage biology |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361316/ https://www.ncbi.nlm.nih.gov/pubmed/37484306 http://dx.doi.org/10.1016/j.heliyon.2023.e17167 |
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